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MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G, Mugen NoE consorti - Nucleic Acids Res. (2007)

Bottom Line: Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms.MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes.Database access is free of charge and there are no registration requirements for data querying.

View Article: PubMed Central - PubMed

Affiliation: B.S.R.C. Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece. v.aidinis@fleming.gr

ABSTRACT
The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

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Related in: MedlinePlus

Querying MMdb. (A) A screen shot demonstrating how database querying can be restricted via choosing from drop down menus (e.g. research application, gene, institution, researcher, mutation type dissemination level and MP term) and also via the function formulating ad hoc queries. (B) Results of an ad hoc query for ‘tnf’. A list with 12 hits of all the available mutant mouse models and related genes is available.
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Figure 3: Querying MMdb. (A) A screen shot demonstrating how database querying can be restricted via choosing from drop down menus (e.g. research application, gene, institution, researcher, mutation type dissemination level and MP term) and also via the function formulating ad hoc queries. (B) Results of an ad hoc query for ‘tnf’. A list with 12 hits of all the available mutant mouse models and related genes is available.

Mentions: MMdb provides a browsing/filtering interface to the underlying data, allowing formulation of queries, in order to narrow down the list of potential results and to coordinate screening of certain mutant strains. Automated drop-down menus that include research applications (model of human disease, model of immune processes, etc.), genes (tumor necrosis factor, CD19 antigen, etc.), institutions, researchers/contact persons or mutation types (insertion, duplication, deletion, targeted, etc.), assigned MP terms (abnormal T cell physiology, abnormal spleen morphology and other already assigned MP terms) or even a combination of the above selections allow further refinement of the mutant strain list according to special characteristics defined by the user (Figure 3A).Figure 3.


MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G, Mugen NoE consorti - Nucleic Acids Res. (2007)

Querying MMdb. (A) A screen shot demonstrating how database querying can be restricted via choosing from drop down menus (e.g. research application, gene, institution, researcher, mutation type dissemination level and MP term) and also via the function formulating ad hoc queries. (B) Results of an ad hoc query for ‘tnf’. A list with 12 hits of all the available mutant mouse models and related genes is available.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2238830&req=5

Figure 3: Querying MMdb. (A) A screen shot demonstrating how database querying can be restricted via choosing from drop down menus (e.g. research application, gene, institution, researcher, mutation type dissemination level and MP term) and also via the function formulating ad hoc queries. (B) Results of an ad hoc query for ‘tnf’. A list with 12 hits of all the available mutant mouse models and related genes is available.
Mentions: MMdb provides a browsing/filtering interface to the underlying data, allowing formulation of queries, in order to narrow down the list of potential results and to coordinate screening of certain mutant strains. Automated drop-down menus that include research applications (model of human disease, model of immune processes, etc.), genes (tumor necrosis factor, CD19 antigen, etc.), institutions, researchers/contact persons or mutation types (insertion, duplication, deletion, targeted, etc.), assigned MP terms (abnormal T cell physiology, abnormal spleen morphology and other already assigned MP terms) or even a combination of the above selections allow further refinement of the mutant strain list according to special characteristics defined by the user (Figure 3A).Figure 3.

Bottom Line: Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms.MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes.Database access is free of charge and there are no registration requirements for data querying.

View Article: PubMed Central - PubMed

Affiliation: B.S.R.C. Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece. v.aidinis@fleming.gr

ABSTRACT
The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

Show MeSH
Related in: MedlinePlus