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MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G, Mugen NoE consorti - Nucleic Acids Res. (2007)

Bottom Line: Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms.MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes.Database access is free of charge and there are no registration requirements for data querying.

View Article: PubMed Central - PubMed

Affiliation: B.S.R.C. Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece. v.aidinis@fleming.gr

ABSTRACT
The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

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Related in: MedlinePlus

Available information and data categorization on a sample mouse model of MMdb. Representative view of a mutant mouse ‘Tnfalpha−/−’ from MMdb, demonstrating all the individual data categorizations and information that are recorded in MMdb (general information, availability, genetic background, strain information, allele and mutations, genes affected, handling and genotyping instructions, phenotype(s) references, author's comments and user's comments).
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Figure 1: Available information and data categorization on a sample mouse model of MMdb. Representative view of a mutant mouse ‘Tnfalpha−/−’ from MMdb, demonstrating all the individual data categorizations and information that are recorded in MMdb (general information, availability, genetic background, strain information, allele and mutations, genes affected, handling and genotyping instructions, phenotype(s) references, author's comments and user's comments).

Mentions: Detailed information is provided for each mutant strain. These are categorized according to the context of the details offered. The first section presents in detail general information on the particular mutant strain: MUGEN ID, the common name in general use for the particular mutant mouse, contact person responsible for the mutant and institution that he/she is affiliated with (Figure 1). Each mutant strain is assigned a research application type denoting if the particular model has been created to serve as a model of ‘human disease’, ‘immune processes’ (i.e. for examining signalling pathways and cellular components involved in immune responses) or a ‘transgenic tool’ (i.e. transgenic mouse lines that provide a powerful tool for generating conditionally mutagenized mouse lines). Finally, relevant additional comments that are entered by the contact person for the respective mutant mouse are also presented. Availability details allow the user to view the repository where the particular mutant strain is housed, as well as its genetic background, strain type and state information (Figure 1).Figure 1.


MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G, Mugen NoE consorti - Nucleic Acids Res. (2007)

Available information and data categorization on a sample mouse model of MMdb. Representative view of a mutant mouse ‘Tnfalpha−/−’ from MMdb, demonstrating all the individual data categorizations and information that are recorded in MMdb (general information, availability, genetic background, strain information, allele and mutations, genes affected, handling and genotyping instructions, phenotype(s) references, author's comments and user's comments).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2238830&req=5

Figure 1: Available information and data categorization on a sample mouse model of MMdb. Representative view of a mutant mouse ‘Tnfalpha−/−’ from MMdb, demonstrating all the individual data categorizations and information that are recorded in MMdb (general information, availability, genetic background, strain information, allele and mutations, genes affected, handling and genotyping instructions, phenotype(s) references, author's comments and user's comments).
Mentions: Detailed information is provided for each mutant strain. These are categorized according to the context of the details offered. The first section presents in detail general information on the particular mutant strain: MUGEN ID, the common name in general use for the particular mutant mouse, contact person responsible for the mutant and institution that he/she is affiliated with (Figure 1). Each mutant strain is assigned a research application type denoting if the particular model has been created to serve as a model of ‘human disease’, ‘immune processes’ (i.e. for examining signalling pathways and cellular components involved in immune responses) or a ‘transgenic tool’ (i.e. transgenic mouse lines that provide a powerful tool for generating conditionally mutagenized mouse lines). Finally, relevant additional comments that are entered by the contact person for the respective mutant mouse are also presented. Availability details allow the user to view the repository where the particular mutant strain is housed, as well as its genetic background, strain type and state information (Figure 1).Figure 1.

Bottom Line: Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms.MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes.Database access is free of charge and there are no registration requirements for data querying.

View Article: PubMed Central - PubMed

Affiliation: B.S.R.C. Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece. v.aidinis@fleming.gr

ABSTRACT
The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

Show MeSH
Related in: MedlinePlus