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Nanotubes spread HIV

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Transient contacts between T cells create nanotubes that may help spread HIV, based on findings from Stefanie Sowinski, Daniel Davis (Imperial College London, UK), and colleagues. “T cells are particularly good at making transient contacts with other cells and then moving on,” says Davis. “It's a specialized function of T cells, natural killer cells, and similar cell types. ” His group now shows that such short-lived greetings often leave in their wake membrane tethers known as nanotubes... These delicate actin-filled tethers have been seen linking neuronal PC12 cells as well as macrophages, B cells, and other immune cell types... Davis and colleagues are currently trying to identify immune cell materials that traffic within the tubes and the functional consequences of any transfer between T cells... Whether nanotubes are used for T cell processes or are a simple byproduct of membrane physics, at least one virus has learned to exploit them... This opportunist is HIV, which invades and replicates within T cells... HIV antigens were found in nanotubes emanating from infected cells... And previously uninfected cells that connected to such nanotubes occasionally wound up with their own allotment of these antigens... Transfer required the viral receptor, CD4, suggesting that HIV transfer between cells by nanotubes requires membrane fusion mediated by HIV's Envelope protein... Reference:

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Nanotubes (red tubes) link cells and can bend around obstacles in a 3D matrix.DAVIS/MACMILLAN
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fig1: Nanotubes (red tubes) link cells and can bend around obstacles in a 3D matrix.DAVIS/MACMILLAN


Nanotubes spread HIV
Nanotubes (red tubes) link cells and can bend around obstacles in a 3D matrix.DAVIS/MACMILLAN
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2234238&req=5

fig1: Nanotubes (red tubes) link cells and can bend around obstacles in a 3D matrix.DAVIS/MACMILLAN

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Transient contacts between T cells create nanotubes that may help spread HIV, based on findings from Stefanie Sowinski, Daniel Davis (Imperial College London, UK), and colleagues. “T cells are particularly good at making transient contacts with other cells and then moving on,” says Davis. “It's a specialized function of T cells, natural killer cells, and similar cell types. ” His group now shows that such short-lived greetings often leave in their wake membrane tethers known as nanotubes... These delicate actin-filled tethers have been seen linking neuronal PC12 cells as well as macrophages, B cells, and other immune cell types... Davis and colleagues are currently trying to identify immune cell materials that traffic within the tubes and the functional consequences of any transfer between T cells... Whether nanotubes are used for T cell processes or are a simple byproduct of membrane physics, at least one virus has learned to exploit them... This opportunist is HIV, which invades and replicates within T cells... HIV antigens were found in nanotubes emanating from infected cells... And previously uninfected cells that connected to such nanotubes occasionally wound up with their own allotment of these antigens... Transfer required the viral receptor, CD4, suggesting that HIV transfer between cells by nanotubes requires membrane fusion mediated by HIV's Envelope protein... Reference:

No MeSH data available.


Related in: MedlinePlus