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Stuck on the membrane

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One reason that impulses can zip through the nervous system is that vesicles filled with neurotransmitters are attached to the membrane, ready to spill their contents into the synapse when a neuron is stimulated... But neurons also release peptides that can increase or reduce the sensitivity of nerve cells... But at least some of these vesicles are docked, researchers have found, so another possibility is that dense core vesicles and neurotransmitter vesicles are attached to the membrane in different ways... Previous work suggests that UNC-13 promotes docking by interacting with a membrane protein called syntaxin... Syntaxin can double over on itself, and UNC-13 probably pries open syntaxin to allow attachment... The results from Hammarlund et al. suggest that CAPS also opens up syntaxin... Their findings also suggest that CAPS and UNC-13 might help docked vesicles fuse with the membrane after stimulation... Dense core vesicles and neurotransmitter vesicles thus appear rely on unique mechanisms to hook onto the membrane... Nailing down how these differences translate into changes in release speed will require further research... Reference:

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Dense core vesicles dock at the membrane (left) or hang back (right).
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fig1: Dense core vesicles dock at the membrane (left) or hang back (right).


Stuck on the membrane
Dense core vesicles dock at the membrane (left) or hang back (right).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2234235&req=5

fig1: Dense core vesicles dock at the membrane (left) or hang back (right).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

One reason that impulses can zip through the nervous system is that vesicles filled with neurotransmitters are attached to the membrane, ready to spill their contents into the synapse when a neuron is stimulated... But neurons also release peptides that can increase or reduce the sensitivity of nerve cells... But at least some of these vesicles are docked, researchers have found, so another possibility is that dense core vesicles and neurotransmitter vesicles are attached to the membrane in different ways... Previous work suggests that UNC-13 promotes docking by interacting with a membrane protein called syntaxin... Syntaxin can double over on itself, and UNC-13 probably pries open syntaxin to allow attachment... The results from Hammarlund et al. suggest that CAPS also opens up syntaxin... Their findings also suggest that CAPS and UNC-13 might help docked vesicles fuse with the membrane after stimulation... Dense core vesicles and neurotransmitter vesicles thus appear rely on unique mechanisms to hook onto the membrane... Nailing down how these differences translate into changes in release speed will require further research... Reference:

No MeSH data available.


Related in: MedlinePlus