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Cleaning the kidney's filter

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Filters in the mammalian kidney must be unclogged by a transport receptor, say Shreeram Akilesh, Andrey Shaw (Washington University, St. Louis, MO), and colleagues... Large and highly charged proteins are mostly kept out of the urine filtrate first by a basement membrane and then by finger-like projections of epithelial cells called podocytes... Shaw's group wondered why the gaps between podocyte projections do not get clogged by the proteins they prevent from passing... The two dominant large proteins in the blood—those mostly likely to cause a clog—are albumin and IgG... Using microarray analyses, the team found that a receptor for these proteins, called FcRn, was expressed in podocytes... An overloaded filter might also explain why kidney failure is often the downfall of patients with lupus. “The autoantibodies in lupus patients aren't so uncommon,” says Shaw. “But with clogging from all the excess antibodies, the kidneys probably cannot get cleared of them in time. ” Because IgG and albumin are not normally found in urinary waste, the authors imagine that they are reabsorbed into the bloodstream in kidney tubules, where sugars and amino acids are also reclaimed... The expression of FcRn in tubules supports this idea... To prove their theory, the authors hope to put FcRn back into podocytes but not tubules of the knockout mice, to see whether IgG is sent out with the urine... Reference:

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The clearance (top; left to right) of IgG (white) from mouse kidney filters is slowed in the absence of FcRn (bottom).SHAW/NAS
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fig1: The clearance (top; left to right) of IgG (white) from mouse kidney filters is slowed in the absence of FcRn (bottom).SHAW/NAS


Cleaning the kidney's filter
The clearance (top; left to right) of IgG (white) from mouse kidney filters is slowed in the absence of FcRn (bottom).SHAW/NAS
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2234234&req=5

fig1: The clearance (top; left to right) of IgG (white) from mouse kidney filters is slowed in the absence of FcRn (bottom).SHAW/NAS

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Filters in the mammalian kidney must be unclogged by a transport receptor, say Shreeram Akilesh, Andrey Shaw (Washington University, St. Louis, MO), and colleagues... Large and highly charged proteins are mostly kept out of the urine filtrate first by a basement membrane and then by finger-like projections of epithelial cells called podocytes... Shaw's group wondered why the gaps between podocyte projections do not get clogged by the proteins they prevent from passing... The two dominant large proteins in the blood—those mostly likely to cause a clog—are albumin and IgG... Using microarray analyses, the team found that a receptor for these proteins, called FcRn, was expressed in podocytes... An overloaded filter might also explain why kidney failure is often the downfall of patients with lupus. “The autoantibodies in lupus patients aren't so uncommon,” says Shaw. “But with clogging from all the excess antibodies, the kidneys probably cannot get cleared of them in time. ” Because IgG and albumin are not normally found in urinary waste, the authors imagine that they are reabsorbed into the bloodstream in kidney tubules, where sugars and amino acids are also reclaimed... The expression of FcRn in tubules supports this idea... To prove their theory, the authors hope to put FcRn back into podocytes but not tubules of the knockout mice, to see whether IgG is sent out with the urine... Reference:

No MeSH data available.


Related in: MedlinePlus