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Proteins gang up on HIV

View Article: PubMed Central

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The researchers show that clusters of defensive proteins inside cells capture viral invaders and promote their destruction... Defensive TRIM5 proteins have a narrow but important job: fending off retroviruses that normally attack other species... The researchers followed HIV particles that invaded HeLa cells modified to produce rhesus monkey TRIM5α... Cytoplasmic bodies and HIV particles cozied up, the team found... However, HIV remained stuck in the cytoplasmic bodies if the researchers added a drug that shuts down the proteasome—the cellular garbage disposal that chops up worn-out or damaged proteins... The team then observed interactions between labeled HIV particles and TRIM5α clusters in living cells... And sometimes a new cytoplasmic body formed around a virus particle... The researchers conclude that shortly after viral entry, TRIM5α ensnares HIV particles and then collaborates with the proteasome to destroy them... The mechanism of destruction is obscure, since an individual virus is too large to fit into the proteasome... But as several TRIM5α proteins that have latched onto an HIV particle get drawn into the proteasome, their pulling might tear the virus to pieces, “like sharks eating a dead whale,” says senior author Thomas Hope... Reference:

No MeSH data available.


Cytoplasmic bodies (red) latch onto HIV particles (green).
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fig1: Cytoplasmic bodies (red) latch onto HIV particles (green).


Proteins gang up on HIV
Cytoplasmic bodies (red) latch onto HIV particles (green).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2234232&req=5

fig1: Cytoplasmic bodies (red) latch onto HIV particles (green).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The researchers show that clusters of defensive proteins inside cells capture viral invaders and promote their destruction... Defensive TRIM5 proteins have a narrow but important job: fending off retroviruses that normally attack other species... The researchers followed HIV particles that invaded HeLa cells modified to produce rhesus monkey TRIM5α... Cytoplasmic bodies and HIV particles cozied up, the team found... However, HIV remained stuck in the cytoplasmic bodies if the researchers added a drug that shuts down the proteasome—the cellular garbage disposal that chops up worn-out or damaged proteins... The team then observed interactions between labeled HIV particles and TRIM5α clusters in living cells... And sometimes a new cytoplasmic body formed around a virus particle... The researchers conclude that shortly after viral entry, TRIM5α ensnares HIV particles and then collaborates with the proteasome to destroy them... The mechanism of destruction is obscure, since an individual virus is too large to fit into the proteasome... But as several TRIM5α proteins that have latched onto an HIV particle get drawn into the proteasome, their pulling might tear the virus to pieces, “like sharks eating a dead whale,” says senior author Thomas Hope... Reference:

No MeSH data available.