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Transcription factor translated in axons

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Cox et al. were originally interested in identifying those mRNAs that are translated in axons, which contain ribosomal machinery that synthesizes signaling proteins and cytoskeletal regulators... In their search, says Jaffrey, “we found something strange, which in many ways had already been discovered about ten years ago. ” That oddity was mRNA for a transcription factor called CREB, which turns on antiapoptotic genes when neurons sense the NGF survival factor... The axonal CREB pool was translated when axons were given NGF, although how the local translation pathway is controlled is not known... A decade ago, CREB was also found in dendrites... The authors applied CREB siRNAs selectively to axons to inhibit its translation there... Without this pool of CREB, neurons no longer survived when their axons encountered NGF... In untreated axons, NGF-induced CREB was seen traveling back toward the cell body along with motor-driven endosomes carrying NGF's receptor and the kinases it activates... The transported CREB sported a phosphate modification known to help it turn on prosurvival genes. “CREB from axons is different from the nuclear pool,” says Jaffrey. “It may undergo axon-specific modifications—phosphorylation, sumoylation, or association with binding proteins—that endow it with specific transcriptional abilities. ” Reference:

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Axons (red) translate their own CREB (green) when given NGF (bottom row).JAFFREY/MACMILLAN
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fig1: Axons (red) translate their own CREB (green) when given NGF (bottom row).JAFFREY/MACMILLAN


Transcription factor translated in axons
Axons (red) translate their own CREB (green) when given NGF (bottom row).JAFFREY/MACMILLAN
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Related In: Results  -  Collection

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fig1: Axons (red) translate their own CREB (green) when given NGF (bottom row).JAFFREY/MACMILLAN

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Cox et al. were originally interested in identifying those mRNAs that are translated in axons, which contain ribosomal machinery that synthesizes signaling proteins and cytoskeletal regulators... In their search, says Jaffrey, “we found something strange, which in many ways had already been discovered about ten years ago. ” That oddity was mRNA for a transcription factor called CREB, which turns on antiapoptotic genes when neurons sense the NGF survival factor... The axonal CREB pool was translated when axons were given NGF, although how the local translation pathway is controlled is not known... A decade ago, CREB was also found in dendrites... The authors applied CREB siRNAs selectively to axons to inhibit its translation there... Without this pool of CREB, neurons no longer survived when their axons encountered NGF... In untreated axons, NGF-induced CREB was seen traveling back toward the cell body along with motor-driven endosomes carrying NGF's receptor and the kinases it activates... The transported CREB sported a phosphate modification known to help it turn on prosurvival genes. “CREB from axons is different from the nuclear pool,” says Jaffrey. “It may undergo axon-specific modifications—phosphorylation, sumoylation, or association with binding proteins—that endow it with specific transcriptional abilities. ” Reference:

No MeSH data available.