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Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction.

Briana DD, Boutsikou M, Baka S, Papadopoulos G, Gourgiotis D, Puchner KP, Hassiakos D, Malamitsi-Puchner A - Mediators Inflamm. (2007)

Bottom Line: Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome.Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012).In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR).

View Article: PubMed Central - PubMed

Affiliation: Second Department of Obstetrics and Gynecology, Athens University Medical School, 11528 Athens, Greece.

ABSTRACT
Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.

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Related in: MedlinePlus

MCP-1 concentrations in the plasma of mothers (MS), fetuses (UC), and neonates on day 1 (N1) and 4 (N4) postpartum in appropriate for gestational age (AGA) and intrauterine growth restricted (IUGR) groups. Bars represent the mean values and error bars one SD of the mean.
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Related In: Results  -  Collection


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fig1: MCP-1 concentrations in the plasma of mothers (MS), fetuses (UC), and neonates on day 1 (N1) and 4 (N4) postpartum in appropriate for gestational age (AGA) and intrauterine growth restricted (IUGR) groups. Bars represent the mean values and error bars one SD of the mean.

Mentions: Determined mean (95% confidence intervals (CI)) values of circulating MCP-1 concentrations in both groups are shown in Figure 1.


Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction.

Briana DD, Boutsikou M, Baka S, Papadopoulos G, Gourgiotis D, Puchner KP, Hassiakos D, Malamitsi-Puchner A - Mediators Inflamm. (2007)

MCP-1 concentrations in the plasma of mothers (MS), fetuses (UC), and neonates on day 1 (N1) and 4 (N4) postpartum in appropriate for gestational age (AGA) and intrauterine growth restricted (IUGR) groups. Bars represent the mean values and error bars one SD of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2234089&req=5

fig1: MCP-1 concentrations in the plasma of mothers (MS), fetuses (UC), and neonates on day 1 (N1) and 4 (N4) postpartum in appropriate for gestational age (AGA) and intrauterine growth restricted (IUGR) groups. Bars represent the mean values and error bars one SD of the mean.
Mentions: Determined mean (95% confidence intervals (CI)) values of circulating MCP-1 concentrations in both groups are shown in Figure 1.

Bottom Line: Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome.Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012).In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR).

View Article: PubMed Central - PubMed

Affiliation: Second Department of Obstetrics and Gynecology, Athens University Medical School, 11528 Athens, Greece.

ABSTRACT
Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.

Show MeSH
Related in: MedlinePlus