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Diagnosis and treatment of severe sepsis.

Claessens YE, Dhainaut JF - Crit Care (2007)

Bottom Line: This has been formalized through the Surviving Sepsis Campaign 'bundles', derived from the recommendations of 11 professional societies, which have promoted global improvement in those practices whose primary goal it is to reduce sepsis-related death.However, difficulties remain in implementing all of the procedures recommended by the experts, despite the apparent pragmatism of those procedures.We summarize the main proposals made by the Surviving Sepsis Campaign and focus on the difficulties associated with making a proper diagnosis and supplying adequate treatment promptly to septic patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pôle Réanimations-Urgences, Hôpital Cochin, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, Paris, France.

ABSTRACT
The burden of infection in industrialized countries has prompted considerable effort to improve the outcomes of patients with sepsis. This has been formalized through the Surviving Sepsis Campaign 'bundles', derived from the recommendations of 11 professional societies, which have promoted global improvement in those practices whose primary goal it is to reduce sepsis-related death. However, difficulties remain in implementing all of the procedures recommended by the experts, despite the apparent pragmatism of those procedures. We summarize the main proposals made by the Surviving Sepsis Campaign and focus on the difficulties associated with making a proper diagnosis and supplying adequate treatment promptly to septic patients.

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Management of severe sepsis in adults in the absence of an immediate life-threatening condition. ABP, arterial blood pressure; ACTH, adrenocorticotropic hormone; Hb, hemoglobin; RBC, red blood cell; ScvO2, central venous oxygen saturation; SpO2, pulse oximetry. Reproduced with permission from Marquis S, Roupie E: Prise en charge précoce du choc septique aux urgences/Early management of septic shock in emergency department. Rèanimation 2006, 15:507–513.
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Figure 1: Management of severe sepsis in adults in the absence of an immediate life-threatening condition. ABP, arterial blood pressure; ACTH, adrenocorticotropic hormone; Hb, hemoglobin; RBC, red blood cell; ScvO2, central venous oxygen saturation; SpO2, pulse oximetry. Reproduced with permission from Marquis S, Roupie E: Prise en charge précoce du choc septique aux urgences/Early management of septic shock in emergency department. Rèanimation 2006, 15:507–513.

Mentions: Despite the strong evidence base, use of adjunctive therapies has remained sparse in the setting of sepsis. Questionnaire surveys have attested to the under-use of such adjunctive therapies. Once again, the need for medical adherence to new therapies must be promoted by implementation of local guidelines that are inspired by the recommendations of the Surviving Sepsis Campaign (Figure 1).


Diagnosis and treatment of severe sepsis.

Claessens YE, Dhainaut JF - Crit Care (2007)

Management of severe sepsis in adults in the absence of an immediate life-threatening condition. ABP, arterial blood pressure; ACTH, adrenocorticotropic hormone; Hb, hemoglobin; RBC, red blood cell; ScvO2, central venous oxygen saturation; SpO2, pulse oximetry. Reproduced with permission from Marquis S, Roupie E: Prise en charge précoce du choc septique aux urgences/Early management of septic shock in emergency department. Rèanimation 2006, 15:507–513.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2230613&req=5

Figure 1: Management of severe sepsis in adults in the absence of an immediate life-threatening condition. ABP, arterial blood pressure; ACTH, adrenocorticotropic hormone; Hb, hemoglobin; RBC, red blood cell; ScvO2, central venous oxygen saturation; SpO2, pulse oximetry. Reproduced with permission from Marquis S, Roupie E: Prise en charge précoce du choc septique aux urgences/Early management of septic shock in emergency department. Rèanimation 2006, 15:507–513.
Mentions: Despite the strong evidence base, use of adjunctive therapies has remained sparse in the setting of sepsis. Questionnaire surveys have attested to the under-use of such adjunctive therapies. Once again, the need for medical adherence to new therapies must be promoted by implementation of local guidelines that are inspired by the recommendations of the Surviving Sepsis Campaign (Figure 1).

Bottom Line: This has been formalized through the Surviving Sepsis Campaign 'bundles', derived from the recommendations of 11 professional societies, which have promoted global improvement in those practices whose primary goal it is to reduce sepsis-related death.However, difficulties remain in implementing all of the procedures recommended by the experts, despite the apparent pragmatism of those procedures.We summarize the main proposals made by the Surviving Sepsis Campaign and focus on the difficulties associated with making a proper diagnosis and supplying adequate treatment promptly to septic patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pôle Réanimations-Urgences, Hôpital Cochin, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, Paris, France.

ABSTRACT
The burden of infection in industrialized countries has prompted considerable effort to improve the outcomes of patients with sepsis. This has been formalized through the Surviving Sepsis Campaign 'bundles', derived from the recommendations of 11 professional societies, which have promoted global improvement in those practices whose primary goal it is to reduce sepsis-related death. However, difficulties remain in implementing all of the procedures recommended by the experts, despite the apparent pragmatism of those procedures. We summarize the main proposals made by the Surviving Sepsis Campaign and focus on the difficulties associated with making a proper diagnosis and supplying adequate treatment promptly to septic patients.

Show MeSH
Related in: MedlinePlus