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Viscosupplementation in the hip: evaluation of hyaluronic acid formulations.

van den Bekerom MP, Rys B, Mulier M - Arch Orthop Trauma Surg (2007)

Bottom Line: The Harris Hip Score increased significantly in two of the three groups compared to baseline, but no statistical significant difference was noted between the groups.Viscosupplementation provides significant pain reduction in two of the three groups.There is no significant difference in duration of the effect of the first infiltration between the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Gelre Hospitals, Apeldoorn, The Netherlands.

ABSTRACT
This study compares three different hyaluronate formulations and evaluates functionality, time of satisfactory pain relief and also the delay in performing a total hip arthroplasty. One hundred and twenty patients (126 hips) received viscosupplementation with one of the three hyaluronate formulations. All patients were candidate for surgical treatment with a total hip arthroplasty. Three different products were consecutively used: Adant, Synocrom or Synvisc. Patients were assessed 6 weeks after each infiltration using Visual Analogue Scale and Harris Hip Score. The Harris Hip Score increased significantly in two of the three groups compared to baseline, but no statistical significant difference was noted between the groups. Viscosupplementation provides significant pain reduction in two of the three groups. There is no significant difference in duration of the effect of the first infiltration between the three groups. The positive effect was still ongoing at the end point of the study in 46 hips: 51% of the patients did not undergo total hip arthroplasty, 3 years after viscosupplementation.

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Kaplan-Meier survival curve of the duration of effect of the first infiltration in days for the three different treatment groups
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Fig3: Kaplan-Meier survival curve of the duration of effect of the first infiltration in days for the three different treatment groups

Mentions: The duration of the effect of the first infiltration in the three groups is shown in a Kaplan-Meier curve (Fig. 3). The first infiltration was the starting point. Endpoints were the second infiltration or operation of the afflicted hip, or when these were not applicable the latest patient contact, which can be considered as ongoing effect.Fig. 3


Viscosupplementation in the hip: evaluation of hyaluronic acid formulations.

van den Bekerom MP, Rys B, Mulier M - Arch Orthop Trauma Surg (2007)

Kaplan-Meier survival curve of the duration of effect of the first infiltration in days for the three different treatment groups
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2228384&req=5

Fig3: Kaplan-Meier survival curve of the duration of effect of the first infiltration in days for the three different treatment groups
Mentions: The duration of the effect of the first infiltration in the three groups is shown in a Kaplan-Meier curve (Fig. 3). The first infiltration was the starting point. Endpoints were the second infiltration or operation of the afflicted hip, or when these were not applicable the latest patient contact, which can be considered as ongoing effect.Fig. 3

Bottom Line: The Harris Hip Score increased significantly in two of the three groups compared to baseline, but no statistical significant difference was noted between the groups.Viscosupplementation provides significant pain reduction in two of the three groups.There is no significant difference in duration of the effect of the first infiltration between the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Gelre Hospitals, Apeldoorn, The Netherlands.

ABSTRACT
This study compares three different hyaluronate formulations and evaluates functionality, time of satisfactory pain relief and also the delay in performing a total hip arthroplasty. One hundred and twenty patients (126 hips) received viscosupplementation with one of the three hyaluronate formulations. All patients were candidate for surgical treatment with a total hip arthroplasty. Three different products were consecutively used: Adant, Synocrom or Synvisc. Patients were assessed 6 weeks after each infiltration using Visual Analogue Scale and Harris Hip Score. The Harris Hip Score increased significantly in two of the three groups compared to baseline, but no statistical significant difference was noted between the groups. Viscosupplementation provides significant pain reduction in two of the three groups. There is no significant difference in duration of the effect of the first infiltration between the three groups. The positive effect was still ongoing at the end point of the study in 46 hips: 51% of the patients did not undergo total hip arthroplasty, 3 years after viscosupplementation.

Show MeSH