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A population-based study of morbidity and mortality in mannose-binding lectin deficiency.

Dahl M, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG - J. Exp. Med. (2004)

Bottom Line: Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers.In conclusion, in this large study in an ethnically homogeneous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls.Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK-2730 Herlev, Denmark.

ABSTRACT
Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death. We investigated associations between MBL deficiency and risk of infection, other common diseases, and death during 24, 24, and 8 yr of follow-up, respectively. We genotyped 9,245 individuals from the adult Danish population for three MBL deficiency alleles, B, C, and D, as opposed to the normal noncarrier A allele. Hospitalization incidence per 10,000 person. yr was 644 in noncarriers compared with 631 in heterozygotes (log-rank: P = 0.39) and 658 in deficiency homozygotes (P = 0.53). Death incidence per 10,000 person. yr was 235 in noncarriers compared with 244 in heterozygotes (P = 0.44) and 274 in deficiency homozygotes (P = 0.12). After stratification by specific cause of hospitalization or death, only hospitalization from cardiovascular disorders was increased in deficiency homozygotes versus noncarriers (P = 0.02). When retested in two case control studies, this association could not be confirmed. Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers. In conclusion, in this large study in an ethnically homogeneous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls. Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.

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Study design.
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fig1: Study design.

Mentions: All subjects who participated in the 1991–1994 examination of the Copenhagen City Heart Study were included in this population-based study (Fig. 1, top; reference 26). The participants aged 20 yr and above were selected randomly after age stratification into 5-yr age groups from among residents of Copenhagen. Of the 17,180 individuals invited, 10,135 participated, 9,259 gave blood, and 9,245 were genotyped for the B, C, and D deficiency alleles of the MBL gene. Details of study procedures (26–29) and some characteristics of nonresponders (30, 31) are described elsewhere. More than 99% were Caucasians of Danish descent. All participants gave written informed consent, and the ethics committee for Copenhagen and Frederiksberg approved the study (no. 100.2039/91).


A population-based study of morbidity and mortality in mannose-binding lectin deficiency.

Dahl M, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG - J. Exp. Med. (2004)

Study design.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2211811&req=5

fig1: Study design.
Mentions: All subjects who participated in the 1991–1994 examination of the Copenhagen City Heart Study were included in this population-based study (Fig. 1, top; reference 26). The participants aged 20 yr and above were selected randomly after age stratification into 5-yr age groups from among residents of Copenhagen. Of the 17,180 individuals invited, 10,135 participated, 9,259 gave blood, and 9,245 were genotyped for the B, C, and D deficiency alleles of the MBL gene. Details of study procedures (26–29) and some characteristics of nonresponders (30, 31) are described elsewhere. More than 99% were Caucasians of Danish descent. All participants gave written informed consent, and the ethics committee for Copenhagen and Frederiksberg approved the study (no. 100.2039/91).

Bottom Line: Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers.In conclusion, in this large study in an ethnically homogeneous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls.Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK-2730 Herlev, Denmark.

ABSTRACT
Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death. We investigated associations between MBL deficiency and risk of infection, other common diseases, and death during 24, 24, and 8 yr of follow-up, respectively. We genotyped 9,245 individuals from the adult Danish population for three MBL deficiency alleles, B, C, and D, as opposed to the normal noncarrier A allele. Hospitalization incidence per 10,000 person. yr was 644 in noncarriers compared with 631 in heterozygotes (log-rank: P = 0.39) and 658 in deficiency homozygotes (P = 0.53). Death incidence per 10,000 person. yr was 235 in noncarriers compared with 244 in heterozygotes (P = 0.44) and 274 in deficiency homozygotes (P = 0.12). After stratification by specific cause of hospitalization or death, only hospitalization from cardiovascular disorders was increased in deficiency homozygotes versus noncarriers (P = 0.02). When retested in two case control studies, this association could not be confirmed. Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers. In conclusion, in this large study in an ethnically homogeneous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls. Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.

Show MeSH
Related in: MedlinePlus