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Experimental study on bioluminescence tomography with multimodality fusion.

Lv Y, Tian J, Cong W, Wang G - Int J Biomed Imaging (2007)

Bottom Line: To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements.In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency.The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.

View Article: PubMed Central - PubMed

Affiliation: Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, P.O. Box 2728, Beijing 100080, China.

ABSTRACT
To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements. In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency. The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.

No MeSH data available.


Related in: MedlinePlus

BLT system and physical phantom. (a) Multiview noncontact BLT prototype;(b) the physical heterogeneous phantom consisting of bone (B), heart (H), lungs (L), andmuscle (M); and (c) a slice scanned by microCT scanner.
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Related In: Results  -  Collection


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fig1: BLT system and physical phantom. (a) Multiview noncontact BLT prototype;(b) the physical heterogeneous phantom consisting of bone (B), heart (H), lungs (L), andmuscle (M); and (c) a slice scanned by microCT scanner.

Mentions: Figure 1(a) shows the BLT prototype for bioluminescence imaging. The main component of the equipment is a cooled CCD camera (Princeton Instruments, USA), which collects optical signals emitted from bioluminescent source in the phantom. The combination of the vertically rotated stage under computer control and the camera realizes the multiview noncontact detection. Whenthe phantom is placed on the stage, we may manually adjust the distance between the lens and thephantom surface through the controlled transport for the best signal acquisition. In addition, theutilization of light-tight enclosure guarantees that the bioluminescence imaging is performed in atotally dark environment.


Experimental study on bioluminescence tomography with multimodality fusion.

Lv Y, Tian J, Cong W, Wang G - Int J Biomed Imaging (2007)

BLT system and physical phantom. (a) Multiview noncontact BLT prototype;(b) the physical heterogeneous phantom consisting of bone (B), heart (H), lungs (L), andmuscle (M); and (c) a slice scanned by microCT scanner.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2211423&req=5

fig1: BLT system and physical phantom. (a) Multiview noncontact BLT prototype;(b) the physical heterogeneous phantom consisting of bone (B), heart (H), lungs (L), andmuscle (M); and (c) a slice scanned by microCT scanner.
Mentions: Figure 1(a) shows the BLT prototype for bioluminescence imaging. The main component of the equipment is a cooled CCD camera (Princeton Instruments, USA), which collects optical signals emitted from bioluminescent source in the phantom. The combination of the vertically rotated stage under computer control and the camera realizes the multiview noncontact detection. Whenthe phantom is placed on the stage, we may manually adjust the distance between the lens and thephantom surface through the controlled transport for the best signal acquisition. In addition, theutilization of light-tight enclosure guarantees that the bioluminescence imaging is performed in atotally dark environment.

Bottom Line: To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements.In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency.The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.

View Article: PubMed Central - PubMed

Affiliation: Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, P.O. Box 2728, Beijing 100080, China.

ABSTRACT
To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements. In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency. The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.

No MeSH data available.


Related in: MedlinePlus