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The hormonal control of food intake.

Coll AP, Farooqi IS, O'Rahilly S - Cell (2007)

Bottom Line: Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system.These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas.In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom.

ABSTRACT
Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

Show MeSH
Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake.AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.
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fig1: Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake.AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.

Mentions: The hypothalamus receives and integrates neural, metabolic, and humoral signals from the periphery. In particular, contained within the arcuate nucleus of the hypothalamus are two populations of cells that are the best characterized leptin-responsive neurons in the brain (Cone, 2005). The first population of neurons express two potent appetite-stimulating (orexigenic) peptides, the melanocortin anatagonist Agouti-related peptide (AgRP) and Neuropeptide Y (NPY). The second population expresses the peptide cocaine and amphetamine-related transcript (CART) and the large precursor peptide pro-opiomelanocortin (POMC). Both sets of neurons project to second-order, melanocortin 4 receptor (MC4R) expressing neurons within the hypothalamus and elsewhere in the brain (Figure 1).


The hormonal control of food intake.

Coll AP, Farooqi IS, O'Rahilly S - Cell (2007)

Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake.AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2202913&req=5

fig1: Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake.AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.
Mentions: The hypothalamus receives and integrates neural, metabolic, and humoral signals from the periphery. In particular, contained within the arcuate nucleus of the hypothalamus are two populations of cells that are the best characterized leptin-responsive neurons in the brain (Cone, 2005). The first population of neurons express two potent appetite-stimulating (orexigenic) peptides, the melanocortin anatagonist Agouti-related peptide (AgRP) and Neuropeptide Y (NPY). The second population expresses the peptide cocaine and amphetamine-related transcript (CART) and the large precursor peptide pro-opiomelanocortin (POMC). Both sets of neurons project to second-order, melanocortin 4 receptor (MC4R) expressing neurons within the hypothalamus and elsewhere in the brain (Figure 1).

Bottom Line: Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system.These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas.In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom.

ABSTRACT
Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

Show MeSH