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Biomechanical simulations of the scoliotic deformation process in the pinealectomized chicken: a preliminary study.

Lafortune P, Aubin CE, Boulanger H, Villemure I, Bagnall KM, Moreau A - Scoliosis (2007)

Bottom Line: The experimental data were used to adapt a FEM previously developed to simulate the scoliosis deformation process in human.The simulations of the spine deformation process are compared with the results of an experimental study including a group of pinealectomized chickens.For the vertebral wedging, a good agreement is also observed between the calculated (28 degrees ) and the observed (25 degrees - 30 degrees ) values.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Mechanical Engineering, Ecole Polytechnique, University of Montreal, P,O, Box 6079, Station Centre-ville, Montreal, Quebec, H3C 3A7, Canada. carl-eric.aubin@polymtl.ca.

ABSTRACT

Background: The basic mechanisms whereby mechanical factors modulate the metabolism of the growing spine remain poorly understood, especially the role of growth adaptation in spinal disorders like in adolescent idiopathic scoliosis (AIS). This paper presents a finite element model (FEM) that was developed to simulate early stages of scoliotic deformities progression using a pinealectomized chicken as animal model.

Methods: The FEM includes basic growth and growth modulation created by the muscle force imbalance. The experimental data were used to adapt a FEM previously developed to simulate the scoliosis deformation process in human. The simulations of the spine deformation process are compared with the results of an experimental study including a group of pinealectomized chickens.

Results: The comparison of the simulation results of the spine deformation process (Cobb angle of 37 degrees ) is in agreement with experimental scoliotic deformities of two representative cases (Cobb angle of 41 degrees and 30 degrees ). For the vertebral wedging, a good agreement is also observed between the calculated (28 degrees ) and the observed (25 degrees - 30 degrees ) values.

Conclusion: The proposed biomechanical model presents a novel approach to realistically simulate the scoliotic deformation process in pinealectomized chickens and investigate different parameters influencing the progression of scoliosis.

No MeSH data available.


Related in: MedlinePlus

Comparison of simulations and clinical curves. Position in the frontal plane of the vertebral bodies for two selected curves and for the simulation (moment values of 14 Nmm). The initial position of the vertebrae is also illustrated.
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Figure 6: Comparison of simulations and clinical curves. Position in the frontal plane of the vertebral bodies for two selected curves and for the simulation (moment values of 14 Nmm). The initial position of the vertebrae is also illustrated.

Mentions: A descriptive comparison of the simulation results with the experimental deformation patterns was made as a preliminary validation. Among the 42 pinealectomized chickens that developed a scoliosis during the experimental study, two of them have been chosen for that purpose. Chickens produce a large variety of deformations, so we are reporting here the results of two cases that showed a single curve, a moderate to important Cobb angle, and an apex located approximately at the middle of the spine. These were considered as typical cases most representative of the single thoracic spine deformity. Figure 6 illustrates a comparison of the numerical and the experimental deformations in the frontal plane obtained when a moment of 14 N.mm was applied.


Biomechanical simulations of the scoliotic deformation process in the pinealectomized chicken: a preliminary study.

Lafortune P, Aubin CE, Boulanger H, Villemure I, Bagnall KM, Moreau A - Scoliosis (2007)

Comparison of simulations and clinical curves. Position in the frontal plane of the vertebral bodies for two selected curves and for the simulation (moment values of 14 Nmm). The initial position of the vertebrae is also illustrated.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2200637&req=5

Figure 6: Comparison of simulations and clinical curves. Position in the frontal plane of the vertebral bodies for two selected curves and for the simulation (moment values of 14 Nmm). The initial position of the vertebrae is also illustrated.
Mentions: A descriptive comparison of the simulation results with the experimental deformation patterns was made as a preliminary validation. Among the 42 pinealectomized chickens that developed a scoliosis during the experimental study, two of them have been chosen for that purpose. Chickens produce a large variety of deformations, so we are reporting here the results of two cases that showed a single curve, a moderate to important Cobb angle, and an apex located approximately at the middle of the spine. These were considered as typical cases most representative of the single thoracic spine deformity. Figure 6 illustrates a comparison of the numerical and the experimental deformations in the frontal plane obtained when a moment of 14 N.mm was applied.

Bottom Line: The experimental data were used to adapt a FEM previously developed to simulate the scoliosis deformation process in human.The simulations of the spine deformation process are compared with the results of an experimental study including a group of pinealectomized chickens.For the vertebral wedging, a good agreement is also observed between the calculated (28 degrees ) and the observed (25 degrees - 30 degrees ) values.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Mechanical Engineering, Ecole Polytechnique, University of Montreal, P,O, Box 6079, Station Centre-ville, Montreal, Quebec, H3C 3A7, Canada. carl-eric.aubin@polymtl.ca.

ABSTRACT

Background: The basic mechanisms whereby mechanical factors modulate the metabolism of the growing spine remain poorly understood, especially the role of growth adaptation in spinal disorders like in adolescent idiopathic scoliosis (AIS). This paper presents a finite element model (FEM) that was developed to simulate early stages of scoliotic deformities progression using a pinealectomized chicken as animal model.

Methods: The FEM includes basic growth and growth modulation created by the muscle force imbalance. The experimental data were used to adapt a FEM previously developed to simulate the scoliosis deformation process in human. The simulations of the spine deformation process are compared with the results of an experimental study including a group of pinealectomized chickens.

Results: The comparison of the simulation results of the spine deformation process (Cobb angle of 37 degrees ) is in agreement with experimental scoliotic deformities of two representative cases (Cobb angle of 41 degrees and 30 degrees ). For the vertebral wedging, a good agreement is also observed between the calculated (28 degrees ) and the observed (25 degrees - 30 degrees ) values.

Conclusion: The proposed biomechanical model presents a novel approach to realistically simulate the scoliotic deformation process in pinealectomized chickens and investigate different parameters influencing the progression of scoliosis.

No MeSH data available.


Related in: MedlinePlus