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Beginning on page 401, Aiken Hobbs et al. describe the localization of the yeast mitochondrial protein Mmm1p, and propose that the protein is part of a complex that controls mitochondrial structure and DNA segregation... Mmm1p was identified previously as a protein involved in mitochondrial structure, since the mitochondria of mmm1 mutants form large, spherical structures instead of the tubular reticular structures found in the periphery of wild-type yeast cells... In the new work, Aiken Hobbs et al. analyzed the localization of a Mmm1p-GFP fusion protein in vivo... Based on their findings, the authors suggest that a protein complex containing Mmm1p forms a connection between the outer and inner mitochondrial membranes and anchors mtDNA nucleoids to the cytoskeletal matrix... Using fluorescence in situ hybridization and time-lapse microscopy of GFP-tagged chromosomal domains, Heun et al. (page 385; also see the Comment by Gilbert on page F11) examined the subnuclear localization of early- and late-firing DNA replication origins... These findings provide the first direct evidence that the VDAC is required for various forms of apoptosis, including Bax-induced apoptosis... The authors propose that Bax and Bak trigger the opening of the VDAC and subsequent cytochrome c release, leading to other mitochondrial changes associated with apoptosis, while Bid and related apoptotic proteins target a different molecule on the mitochondrial outer membrane.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Beginning on page 401, Aiken Hobbs et al. describe the localization of the yeast mitochondrial protein Mmm1p, and propose that the protein is part of a complex that controls mitochondrial structure and DNA segregation... Mmm1p was identified previously as a protein involved in mitochondrial structure, since the mitochondria of mmm1 mutants form large, spherical structures instead of the tubular reticular structures found in the periphery of wild-type yeast cells... In the new work, Aiken Hobbs et al. analyzed the localization of a Mmm1p-GFP fusion protein in vivo... Based on their findings, the authors suggest that a protein complex containing Mmm1p forms a connection between the outer and inner mitochondrial membranes and anchors mtDNA nucleoids to the cytoskeletal matrix... Using fluorescence in situ hybridization and time-lapse microscopy of GFP-tagged chromosomal domains, Heun et al. (page 385; also see the Comment by Gilbert on page F11) examined the subnuclear localization of early- and late-firing DNA replication origins... These findings provide the first direct evidence that the VDAC is required for various forms of apoptosis, including Bax-induced apoptosis... The authors propose that Bax and Bak trigger the opening of the VDAC and subsequent cytochrome c release, leading to other mitochondrial changes associated with apoptosis, while Bid and related apoptotic proteins target a different molecule on the mitochondrial outer membrane.

No MeSH data available.