Limits...
Sensory and cognitive effects of acute exposure to hydrogen sulfide.

Fiedler N, Kipen H, Ohman-Strickland P, Zhang J, Weisel C, Laumbach R, Kelly-McNeil K, Olejeme K, Lioy P - Environ. Health Perspect. (2008)

Bottom Line: Dose-response reduction in air quality and increases in ratings of odor intensity, irritation, and unpleasantness were observed.No dose-response effect was observed for sensory or cognitive measures.Increased anxiety was significantly related to ratings of irritation due to odor.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, 170 Frelinghuysen Rd., Rm. 210, Piscataway, NJ 08854 USA.. nfiedler@eohsi.rutgers.edu <nfiedler@eohsi.rutgers.edu>

ABSTRACT

Background: Some epidemiologic studies have reported compromised cognitive and sensory performance among individuals exposed to low concentrations of hydrogen sulfide (H2S).

Objectives: We hypothesized a dose-response increase in symptom severity and reduction in sensory and cognitive performance in response to controlled H2S exposures.

Methods: In separate exposure sessions administered in random order over three consecutive weeks, 74 healthy subjects [35 females, 39 males; mean age (+/- SD) = 24.7 +/- 4.2; mean years of education = 16.5 +/- 2.4], were exposed to 0.05, 0.5, and 5 ppm H2S. During each exposure session, subjects completed ratings and tests before H2S exposure (baseline) and during the final hour of the 2-hr exposure period.

Results: Dose-response reduction in air quality and increases in ratings of odor intensity, irritation, and unpleasantness were observed. Total symptom severity was not significantly elevated across any exposure condition, but anxiety symptoms were significantly greater in the 5-ppm than in the 0.05-ppm condition. No dose-response effect was observed for sensory or cognitive measures. Verbal learning was compromised during each exposure condition.

Conclusions: Although some symptoms increased with exposure, the magnitude of these changes was relatively minor. Increased anxiety was significantly related to ratings of irritation due to odor. Whether the effect on verbal learning represents a threshold effect of H2S or an effect due to fatigue across exposure requires further investigation. These acute effects in a healthy sample cannot be directly generalized to communities where individuals have other health conditions and concomitant exposures.

Show MeSH

Related in: MedlinePlus

Controlled environment facility: technician and exposure stations.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2199294&req=5

f1-ehp0116-000078: Controlled environment facility: technician and exposure stations.

Mentions: Before participation, subjects were sent information about the study requirements and the informed consent document. On arrival, subjects were taken to a room where they were given a verbal explanation of the study and the opportunity to ask and have questions answered before signing the consent. Subjects then completed a medical history and physical examination by an occupational physician and performed spirometry, electrocardiogram (EKG), blood counts and routine chemistries, and visual acuity testing. To reduce anxiety, subjects were shown the controlled environment facility (CEF), where they were taught the procedures for the exposure conditions (Figure 1).


Sensory and cognitive effects of acute exposure to hydrogen sulfide.

Fiedler N, Kipen H, Ohman-Strickland P, Zhang J, Weisel C, Laumbach R, Kelly-McNeil K, Olejeme K, Lioy P - Environ. Health Perspect. (2008)

Controlled environment facility: technician and exposure stations.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2199294&req=5

f1-ehp0116-000078: Controlled environment facility: technician and exposure stations.
Mentions: Before participation, subjects were sent information about the study requirements and the informed consent document. On arrival, subjects were taken to a room where they were given a verbal explanation of the study and the opportunity to ask and have questions answered before signing the consent. Subjects then completed a medical history and physical examination by an occupational physician and performed spirometry, electrocardiogram (EKG), blood counts and routine chemistries, and visual acuity testing. To reduce anxiety, subjects were shown the controlled environment facility (CEF), where they were taught the procedures for the exposure conditions (Figure 1).

Bottom Line: Dose-response reduction in air quality and increases in ratings of odor intensity, irritation, and unpleasantness were observed.No dose-response effect was observed for sensory or cognitive measures.Increased anxiety was significantly related to ratings of irritation due to odor.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, 170 Frelinghuysen Rd., Rm. 210, Piscataway, NJ 08854 USA.. nfiedler@eohsi.rutgers.edu <nfiedler@eohsi.rutgers.edu>

ABSTRACT

Background: Some epidemiologic studies have reported compromised cognitive and sensory performance among individuals exposed to low concentrations of hydrogen sulfide (H2S).

Objectives: We hypothesized a dose-response increase in symptom severity and reduction in sensory and cognitive performance in response to controlled H2S exposures.

Methods: In separate exposure sessions administered in random order over three consecutive weeks, 74 healthy subjects [35 females, 39 males; mean age (+/- SD) = 24.7 +/- 4.2; mean years of education = 16.5 +/- 2.4], were exposed to 0.05, 0.5, and 5 ppm H2S. During each exposure session, subjects completed ratings and tests before H2S exposure (baseline) and during the final hour of the 2-hr exposure period.

Results: Dose-response reduction in air quality and increases in ratings of odor intensity, irritation, and unpleasantness were observed. Total symptom severity was not significantly elevated across any exposure condition, but anxiety symptoms were significantly greater in the 5-ppm than in the 0.05-ppm condition. No dose-response effect was observed for sensory or cognitive measures. Verbal learning was compromised during each exposure condition.

Conclusions: Although some symptoms increased with exposure, the magnitude of these changes was relatively minor. Increased anxiety was significantly related to ratings of irritation due to odor. Whether the effect on verbal learning represents a threshold effect of H2S or an effect due to fatigue across exposure requires further investigation. These acute effects in a healthy sample cannot be directly generalized to communities where individuals have other health conditions and concomitant exposures.

Show MeSH
Related in: MedlinePlus