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Guest Editorial: NTP: New Initiatives, New Alignment

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I accepted this challenge with enthusiasm and pledged to a) maintain our traditional areas of strength in toxicology research and testing; b) accelerate our efforts to fulfill the goals set forth in A National Toxicology Program for the 21st Century: A Roadmap for the Future ; and c) explore new scientific opportunities to understand how individual genetic susceptibilities affect responses to environmental exposures... Events surrounding the review of bisphenol A by an expert panel convened to provide advice to the NTP Center for the Evaluation of Risks to Human Reproduction led to reviews of all NTP contracts for potential conflicts of interest... This attention highlighted a long-recognized need for a change in our alignment within the NIEHS Division of Intramural Research (DIR)... The need was to give a clearer identity to activities, staff, and dollars associated with the NTP, because for well over a decade these resources had been scattered across several DIR programs... The budget for this new program will include funding for research and development (R&D) contracts, staff salaries, equipment, and travel... R&D contracts have traditionally provided NTP capabilities for research and testing functions, as well as providing technical and administrative support for analysis activities such as CERHR evaluations... Building on the recent NIEHS/NTP effort to determine dense single-nucleotide polymorphism maps of 15 commonly used strains of laboratory mice, and drawing upon the wide variety of transgenic and knock-out mice now available, staff are devising an innovative approach to collaborative research... This will involve soliciting ideas for specific research projects from academic, government, and possibly private research entities, and using NTP contracts and small grants to perform studies with multiple isogenic lines of genetically defined mice to provide phenotypic data for gene association studies... I am confident that the research and testing programs of the NTP will continue to provide critical toxicology information on substances of concern to regulatory agencies and the public... Our commitment to public peer review of NTP scientific documents and public input through new nominations and comments to the program is strong... We pledge to continue to work with our agency partners and our scientific advisory boards to provide “good science for good decisions. ”

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John R. Bucher
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f1-ehp0116-a00014: John R. Bucher


Guest Editorial: NTP: New Initiatives, New Alignment
John R. Bucher
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2199275&req=5

f1-ehp0116-a00014: John R. Bucher

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

I accepted this challenge with enthusiasm and pledged to a) maintain our traditional areas of strength in toxicology research and testing; b) accelerate our efforts to fulfill the goals set forth in A National Toxicology Program for the 21st Century: A Roadmap for the Future ; and c) explore new scientific opportunities to understand how individual genetic susceptibilities affect responses to environmental exposures... Events surrounding the review of bisphenol A by an expert panel convened to provide advice to the NTP Center for the Evaluation of Risks to Human Reproduction led to reviews of all NTP contracts for potential conflicts of interest... This attention highlighted a long-recognized need for a change in our alignment within the NIEHS Division of Intramural Research (DIR)... The need was to give a clearer identity to activities, staff, and dollars associated with the NTP, because for well over a decade these resources had been scattered across several DIR programs... The budget for this new program will include funding for research and development (R&D) contracts, staff salaries, equipment, and travel... R&D contracts have traditionally provided NTP capabilities for research and testing functions, as well as providing technical and administrative support for analysis activities such as CERHR evaluations... Building on the recent NIEHS/NTP effort to determine dense single-nucleotide polymorphism maps of 15 commonly used strains of laboratory mice, and drawing upon the wide variety of transgenic and knock-out mice now available, staff are devising an innovative approach to collaborative research... This will involve soliciting ideas for specific research projects from academic, government, and possibly private research entities, and using NTP contracts and small grants to perform studies with multiple isogenic lines of genetically defined mice to provide phenotypic data for gene association studies... I am confident that the research and testing programs of the NTP will continue to provide critical toxicology information on substances of concern to regulatory agencies and the public... Our commitment to public peer review of NTP scientific documents and public input through new nominations and comments to the program is strong... We pledge to continue to work with our agency partners and our scientific advisory boards to provide “good science for good decisions. ”

No MeSH data available.