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Mitigating methylmercury exposure.

Freeman K - Environ. Health Perspect. (2008)

View Article: PubMed Central - PubMed

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Researchers have been searching for better ways to quantify and mitigate exposures to the neurotoxicant methylmercury (MeHg)... Treatments to mitigate MeHg exposure involve chelation, the administration of compounds that bind mercury, speeding its elimination from the body and thereby minimizing its toxicity... Current chelation methods can be nonspecific, depleting not only MeHg but also minerals required for normal cell function, such as calcium... In contrast, chelation treatment with NAC does not affect levels of essential minerals... In the current study, adult rats were injected with NAC (1 mmol/kg) 2 hours after being exposed to MeHg (0.1 μmol/kg)... The treated animals excreted about 5% of their body burden of MeHg within 2 hours, compared with less than 0.1% excreted by untreated animals... The response was transient and dose dependent, with larger doses of NAC resulting in higher rates of MeHg excretion... These effects were not seen in preweaned rats (age 15–19 days) treated with NAC... The researchers speculate that the transporter systems needed to move the MeHg–NAC complex through the kidney do not mature until animals reach adulthood (around 30 days of age)... However, oral NAC treatment in pregnant rats (10 mg/mL in drinking water) did protect their fetuses, reducing concentrations in the placenta and the whole fetus by 70–90%... In the dams themselves, NAC also reduced MeHg concentrations by 70–90% in the brain, by about 20% in the kidney, and by 60–80% in the blood and liver... According to the researchers, such a quick-acting biomarker could provide critical early warning of possible acute exposures, where early treatment is critical to prevent neurological damage... In contrast, standard monitoring techniques, which use hair analysis, can provide only a history of exposure and cannot guide immediate treatment for acute exposures.

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NAC offers promise as an antidote to acute MeHg exposure
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f1-ehp0116-a0036a: NAC offers promise as an antidote to acute MeHg exposure


Mitigating methylmercury exposure.

Freeman K - Environ. Health Perspect. (2008)

NAC offers promise as an antidote to acute MeHg exposure
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2199274&req=5

f1-ehp0116-a0036a: NAC offers promise as an antidote to acute MeHg exposure

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Researchers have been searching for better ways to quantify and mitigate exposures to the neurotoxicant methylmercury (MeHg)... Treatments to mitigate MeHg exposure involve chelation, the administration of compounds that bind mercury, speeding its elimination from the body and thereby minimizing its toxicity... Current chelation methods can be nonspecific, depleting not only MeHg but also minerals required for normal cell function, such as calcium... In contrast, chelation treatment with NAC does not affect levels of essential minerals... In the current study, adult rats were injected with NAC (1 mmol/kg) 2 hours after being exposed to MeHg (0.1 μmol/kg)... The treated animals excreted about 5% of their body burden of MeHg within 2 hours, compared with less than 0.1% excreted by untreated animals... The response was transient and dose dependent, with larger doses of NAC resulting in higher rates of MeHg excretion... These effects were not seen in preweaned rats (age 15–19 days) treated with NAC... The researchers speculate that the transporter systems needed to move the MeHg–NAC complex through the kidney do not mature until animals reach adulthood (around 30 days of age)... However, oral NAC treatment in pregnant rats (10 mg/mL in drinking water) did protect their fetuses, reducing concentrations in the placenta and the whole fetus by 70–90%... In the dams themselves, NAC also reduced MeHg concentrations by 70–90% in the brain, by about 20% in the kidney, and by 60–80% in the blood and liver... According to the researchers, such a quick-acting biomarker could provide critical early warning of possible acute exposures, where early treatment is critical to prevent neurological damage... In contrast, standard monitoring techniques, which use hair analysis, can provide only a history of exposure and cannot guide immediate treatment for acute exposures.

Show MeSH
Related in: MedlinePlus