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Only cells that contain, or are transfected with, angiomotin show the following responses to angiostatin: the internalization of angiostatin, an increase in FAK kinase activity, a reduction of both background and growth-factor induced migration rates, and an inhibition of tubulogenesis... As discussed in a comment by Zetter (page F35), angiomotin's localization at the leading edge of migrating cells suggests that it is normally involved in migration, and that the binding of angiostatin to angiomotin may disrupt this function... Kuo et al. report that addition of c18 NC1 prevents endothelial cells from aggregating into tubules in matrigel, and stimulates migration of cells away from preformed tubules... These worms, which lack only the NC1 domain of CLE-1, show defects in cell migration and axon guidance... Instead, it prevents rescue by coexpressed CLE-1 NC1 and causes dominant migration defects in a wild-type background... Previously, RAGE had been implicated in certain forms of atherosclerosis associated with diabetes... The work of Degryse et al. suggests that HMG1 may be an even more important ligand for this receptor than the advanced glycation endproducts that are produced during hyperglycemia.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Only cells that contain, or are transfected with, angiomotin show the following responses to angiostatin: the internalization of angiostatin, an increase in FAK kinase activity, a reduction of both background and growth-factor induced migration rates, and an inhibition of tubulogenesis... As discussed in a comment by Zetter (page F35), angiomotin's localization at the leading edge of migrating cells suggests that it is normally involved in migration, and that the binding of angiostatin to angiomotin may disrupt this function... Kuo et al. report that addition of c18 NC1 prevents endothelial cells from aggregating into tubules in matrigel, and stimulates migration of cells away from preformed tubules... These worms, which lack only the NC1 domain of CLE-1, show defects in cell migration and axon guidance... Instead, it prevents rescue by coexpressed CLE-1 NC1 and causes dominant migration defects in a wild-type background... Previously, RAGE had been implicated in certain forms of atherosclerosis associated with diabetes... The work of Degryse et al. suggests that HMG1 may be an even more important ligand for this receptor than the advanced glycation endproducts that are produced during hyperglycemia.

No MeSH data available.