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Auditory target processing in methadone substituted opiate addicts: the effect of nicotine in controls.

Müller BW, Specka M, Steinchen N, Zerbin D, Lodemann E, Finkbeiner T, Scherbaum N - BMC Psychiatry (2007)

Bottom Line: Subgroup analyses revealed significantly reduced P300 amplitudes in controls with nicotine use when compared to those without.No P300 latency effects were found.The effect of nicotine on P300 amplitudes in healthy subjects exceeds the effects of long term opioid addiction under methadone substitution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinic for Addictive Behaviour and Addiction Medicine, University of Duisburg-Essen, Virchowstr, 174, 45147 Essen, Germany. bernhard.mueller@uni-due.de

ABSTRACT

Background: The P300 component of the auditory evoked potential is an indicator of attention dependent target processing. Only a few studies have assessed cognitive function in substituted opiate addicts by means of evoked potential recordings. In addition, P300 data suggest that chronic nicotine use reduces P300 amplitudes. While nicotine and opiate effects combine in addicted subjects, here we investigated the P300 component of the auditory event related potential in methadone substituted opiate addicts with and without concomitant non-opioid drug use in comparison to a group of control subjects with and without nicotine consumption.

Methods: We assessed 47 opiate addicted out-patients under current methadone substitution and 65 control subjects matched for age and gender in an 2-stimulus auditory oddball paradigm. Patients were grouped for those with and without additional non-opioid drug use and controls were grouped for current nicotine use. P300 amplitude and latency data were analyzed at electrodes Fz, Cz and Pz.

Results: Patients and controls did not differ with regard to P300 amplitudes and latencies when whole groups were compared. Subgroup analyses revealed significantly reduced P300 amplitudes in controls with nicotine use when compared to those without. P300 amplitudes of methadone substituted opiate addicts were in between the two control groups and did not differ with regard to additional non-opioid use. Controls with nicotine had lower P300 amplitudes when compared to patients with concomitant non-opioid drugs. No P300 latency effects were found.

Conclusion: Attention dependent target processing as indexed by the P300 component amplitudes and latencies is not reduced in methadone substituted opiate addicts when compared to controls. The effect of nicotine on P300 amplitudes in healthy subjects exceeds the effects of long term opioid addiction under methadone substitution.

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P300 ERP grand average plots. ERP grand average plots at electrodes Fz, Cz and Pz (μV) in subgroups of methadone substituted patients with and without additional non-opioid drug use and in controls with and without nicotine use. Note: according to electrophysiological convention negative evoked potential data are shown upwards.
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Figure 1: P300 ERP grand average plots. ERP grand average plots at electrodes Fz, Cz and Pz (μV) in subgroups of methadone substituted patients with and without additional non-opioid drug use and in controls with and without nicotine use. Note: according to electrophysiological convention negative evoked potential data are shown upwards.

Mentions: The effect of nicotine in controls (with and without) and the effect of additional non-opioid drug use was assessed in a repeated measurements ANOVA with group as between factor and electrodes (Fz, Cz, Pz) as within factor, see Figure 1. This analysis revealed a significant group main effect (F[3;107] = 5.07, p = 0.003) but no significant electrode × group interaction (F[4.6;164.1] = 0.79, p = 0.57) when controlling for the effect of education (F[1;107] = 3.4, p = 0.07). Group effects were further evaluated in group × electrode follow up analyses. Concomitant non-opioid drug use versus no concomitant drug use had no effect on P300 amplitudes (main effect group: p = 0.69, group × electrode interaction p = 0.88). Among controls, nicotine consumption had a major impact on P300 amplitudes with a significant group effect (p < 0.001) but no significant electrode × group interaction. Control subjects without nicotine consumption were not significantly different from patients with (p = 0.20) or without (p = 0.09) concomitant non-opioid drug use. Control subjects with nicotine consumption differed significantly from patients with concomitant non-opioid use (p = 0.02) but not from those without (p = 0.10). We found no significant group × electrode interactions in any of these analyses, see Figure 2.


Auditory target processing in methadone substituted opiate addicts: the effect of nicotine in controls.

Müller BW, Specka M, Steinchen N, Zerbin D, Lodemann E, Finkbeiner T, Scherbaum N - BMC Psychiatry (2007)

P300 ERP grand average plots. ERP grand average plots at electrodes Fz, Cz and Pz (μV) in subgroups of methadone substituted patients with and without additional non-opioid drug use and in controls with and without nicotine use. Note: according to electrophysiological convention negative evoked potential data are shown upwards.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2198909&req=5

Figure 1: P300 ERP grand average plots. ERP grand average plots at electrodes Fz, Cz and Pz (μV) in subgroups of methadone substituted patients with and without additional non-opioid drug use and in controls with and without nicotine use. Note: according to electrophysiological convention negative evoked potential data are shown upwards.
Mentions: The effect of nicotine in controls (with and without) and the effect of additional non-opioid drug use was assessed in a repeated measurements ANOVA with group as between factor and electrodes (Fz, Cz, Pz) as within factor, see Figure 1. This analysis revealed a significant group main effect (F[3;107] = 5.07, p = 0.003) but no significant electrode × group interaction (F[4.6;164.1] = 0.79, p = 0.57) when controlling for the effect of education (F[1;107] = 3.4, p = 0.07). Group effects were further evaluated in group × electrode follow up analyses. Concomitant non-opioid drug use versus no concomitant drug use had no effect on P300 amplitudes (main effect group: p = 0.69, group × electrode interaction p = 0.88). Among controls, nicotine consumption had a major impact on P300 amplitudes with a significant group effect (p < 0.001) but no significant electrode × group interaction. Control subjects without nicotine consumption were not significantly different from patients with (p = 0.20) or without (p = 0.09) concomitant non-opioid drug use. Control subjects with nicotine consumption differed significantly from patients with concomitant non-opioid use (p = 0.02) but not from those without (p = 0.10). We found no significant group × electrode interactions in any of these analyses, see Figure 2.

Bottom Line: Subgroup analyses revealed significantly reduced P300 amplitudes in controls with nicotine use when compared to those without.No P300 latency effects were found.The effect of nicotine on P300 amplitudes in healthy subjects exceeds the effects of long term opioid addiction under methadone substitution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinic for Addictive Behaviour and Addiction Medicine, University of Duisburg-Essen, Virchowstr, 174, 45147 Essen, Germany. bernhard.mueller@uni-due.de

ABSTRACT

Background: The P300 component of the auditory evoked potential is an indicator of attention dependent target processing. Only a few studies have assessed cognitive function in substituted opiate addicts by means of evoked potential recordings. In addition, P300 data suggest that chronic nicotine use reduces P300 amplitudes. While nicotine and opiate effects combine in addicted subjects, here we investigated the P300 component of the auditory event related potential in methadone substituted opiate addicts with and without concomitant non-opioid drug use in comparison to a group of control subjects with and without nicotine consumption.

Methods: We assessed 47 opiate addicted out-patients under current methadone substitution and 65 control subjects matched for age and gender in an 2-stimulus auditory oddball paradigm. Patients were grouped for those with and without additional non-opioid drug use and controls were grouped for current nicotine use. P300 amplitude and latency data were analyzed at electrodes Fz, Cz and Pz.

Results: Patients and controls did not differ with regard to P300 amplitudes and latencies when whole groups were compared. Subgroup analyses revealed significantly reduced P300 amplitudes in controls with nicotine use when compared to those without. P300 amplitudes of methadone substituted opiate addicts were in between the two control groups and did not differ with regard to additional non-opioid use. Controls with nicotine had lower P300 amplitudes when compared to patients with concomitant non-opioid drugs. No P300 latency effects were found.

Conclusion: Attention dependent target processing as indexed by the P300 component amplitudes and latencies is not reduced in methadone substituted opiate addicts when compared to controls. The effect of nicotine on P300 amplitudes in healthy subjects exceeds the effects of long term opioid addiction under methadone substitution.

Show MeSH
Related in: MedlinePlus