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Now Fu et al. (page 1019) have used the actin-binding protein talin, linked to an enhanced green fluorescent protein (GFP), to detect sparse and transient short actin bundles (SABs) in pollen tips... In the fifteen years since kinesin was identified in squid axoplasm, the cargoes that directly bind to this microtubule-based motor have eluded researchers, perhaps because most kinesin is not bound to cargo at any one time... However, on page 1033 Kabir et al. report that PKC has only minor effects on neurite actin dynamics, but dramatically stimulates microtubule growth into the peripheral (P) zone of growth cones, from which microtubules are normally excluded... On page 1007, Zervas et al. report that Drosophila melanogaster ILK helps connect the actin cytoskeleton to the plasma membrane, but is not necessary for the activity of the integrin, protein kinase B (PKB), or Wnt signaling pathways... Furthermore, ILK's essential function does not require an active kinase domain, suggesting that ILK is acting primarily as a linker and not as a signal transducer... Further extension of the 100-nm form reduces the size of the bead and appears to be irreversible, probably because it breaks a covalent transglutaminase cross-link... This model fits the available data, but Baldock et al. hope to test the model further by using atomic force microscopy to see if protein hinges are in the predicted locations.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Now Fu et al. (page 1019) have used the actin-binding protein talin, linked to an enhanced green fluorescent protein (GFP), to detect sparse and transient short actin bundles (SABs) in pollen tips... In the fifteen years since kinesin was identified in squid axoplasm, the cargoes that directly bind to this microtubule-based motor have eluded researchers, perhaps because most kinesin is not bound to cargo at any one time... However, on page 1033 Kabir et al. report that PKC has only minor effects on neurite actin dynamics, but dramatically stimulates microtubule growth into the peripheral (P) zone of growth cones, from which microtubules are normally excluded... On page 1007, Zervas et al. report that Drosophila melanogaster ILK helps connect the actin cytoskeleton to the plasma membrane, but is not necessary for the activity of the integrin, protein kinase B (PKB), or Wnt signaling pathways... Furthermore, ILK's essential function does not require an active kinase domain, suggesting that ILK is acting primarily as a linker and not as a signal transducer... Further extension of the 100-nm form reduces the size of the bead and appears to be irreversible, probably because it breaks a covalent transglutaminase cross-link... This model fits the available data, but Baldock et al. hope to test the model further by using atomic force microscopy to see if protein hinges are in the predicted locations.

No MeSH data available.