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Two papers from the same laboratory (Arin et al., page 645 and Cao et al., page 651), describe the use of an inducible gene targeting strategy to develop mouse models for serious human skin diseases... Assaad et al. (page 531) positionally cloned KEULE, a gene required for cytokinesis in Arabidopsis thaliana, and determined that it encodes a Sec1 protein that interacts with a vesicle-trafficking syntaxin... Beginning on page 633, Aoudjit and Vuori report that matrix attachment regulates Fas-mediated apoptosis by modulating the expression levels of the death receptor Fas and the caspase-8 antagonist c-Flip... Using both a chimeric mouse model and isolated myotubes generated from embryonic stem cells, Jacobson et al. (page 435) have gained significant new insights into the role of dystroglycans in the organization of the neuromuscular junction (NMJ)... Newmyer and Schmid (page 607) have demonstrated that the heat shock cognate protein hsc70 not only regulates coat disassembly in the clathrin coated vesicle (CCV) cycle, but also appears to have a broader role in modulating clathrin dynamics throughout the CCV cycle... Based on their results, Newmyer and Schmid propose that hsc70 may act in endosomal trafficking as a chaperone for cytosolic clathrin... In this model, hsc70 might regulate multiple steps in the CCV cycle by preventing clathrin from inappropriately self-assembling.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Two papers from the same laboratory (Arin et al., page 645 and Cao et al., page 651), describe the use of an inducible gene targeting strategy to develop mouse models for serious human skin diseases... Assaad et al. (page 531) positionally cloned KEULE, a gene required for cytokinesis in Arabidopsis thaliana, and determined that it encodes a Sec1 protein that interacts with a vesicle-trafficking syntaxin... Beginning on page 633, Aoudjit and Vuori report that matrix attachment regulates Fas-mediated apoptosis by modulating the expression levels of the death receptor Fas and the caspase-8 antagonist c-Flip... Using both a chimeric mouse model and isolated myotubes generated from embryonic stem cells, Jacobson et al. (page 435) have gained significant new insights into the role of dystroglycans in the organization of the neuromuscular junction (NMJ)... Newmyer and Schmid (page 607) have demonstrated that the heat shock cognate protein hsc70 not only regulates coat disassembly in the clathrin coated vesicle (CCV) cycle, but also appears to have a broader role in modulating clathrin dynamics throughout the CCV cycle... Based on their results, Newmyer and Schmid propose that hsc70 may act in endosomal trafficking as a chaperone for cytosolic clathrin... In this model, hsc70 might regulate multiple steps in the CCV cycle by preventing clathrin from inappropriately self-assembling.

No MeSH data available.