Limits...
Design of Lamifuse: a randomised, multi-centre controlled trial comparing laminectomy without or with dorsal fusion for cervical myeloradiculopathy.

Bartels RH, Verbeek AL, Grotenhuis JA - BMC Musculoskelet Disord (2007)

Bottom Line: Immobilisation by fusion could have a positive effect on the recovery of myelopathic signs or changes.This study will contribute to the discussion whether additional fusion after a cervical laminectomy results in a better clinical outcome.ISRCT NUMBER: ISRCTN72800446.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. r.bartels@nch.umcn.nl

ABSTRACT

Background: laminectomy is a valuable surgical treatment for some patients with a cervical radiculomyelopathy due to cervical spinal stenosis. More recently attention has been given to motion of the spinal cord over spondylotic spurs as a cause of myelopathic changes. Immobilisation by fusion could have a positive effect on the recovery of myelopathic signs or changes. This has never been investigated in a prospective, randomised trial. Lamifuse is an acronyme for laminectomy and fusion.

Methods/design: Lamifuse is a multicentre, randomised controlled trial comparing laminectomy with and without fusion in patients with a symptomatic cervical canal stenosis. The study population will be enrolled from patients that are 60 years or older with myelopathic signs and/or symptoms due to a cervical canal stenosis. A kyphotis shape of the cervical spine is an exclusion criterium. Each treatment arm needs 30 patients.

Discussion: This study will contribute to the discussion whether additional fusion after a cervical laminectomy results in a better clinical outcome. ISRCT NUMBER: ISRCTN72800446.

Show MeSH

Related in: MedlinePlus

Modified Japanese Orthopaedic Association functional score.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2194678&req=5

Figure 2: Modified Japanese Orthopaedic Association functional score.

Mentions: Several score systems exist for grading the severity of cervical myelopathy. The modified Japanese Orthopedic functional score (Fig. 2) evaluates four groups: the function of the arms, of the legs, the micturation, and the sensibility of the hands. It has the major advantage that it assesses these functions separately [10]. Although it has been established that outcome after decompressive surgery reaches a plateau at six months postoperatively [13], the primary endpoint will be evaluated at one year postoperatively just to make sure.


Design of Lamifuse: a randomised, multi-centre controlled trial comparing laminectomy without or with dorsal fusion for cervical myeloradiculopathy.

Bartels RH, Verbeek AL, Grotenhuis JA - BMC Musculoskelet Disord (2007)

Modified Japanese Orthopaedic Association functional score.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2194678&req=5

Figure 2: Modified Japanese Orthopaedic Association functional score.
Mentions: Several score systems exist for grading the severity of cervical myelopathy. The modified Japanese Orthopedic functional score (Fig. 2) evaluates four groups: the function of the arms, of the legs, the micturation, and the sensibility of the hands. It has the major advantage that it assesses these functions separately [10]. Although it has been established that outcome after decompressive surgery reaches a plateau at six months postoperatively [13], the primary endpoint will be evaluated at one year postoperatively just to make sure.

Bottom Line: Immobilisation by fusion could have a positive effect on the recovery of myelopathic signs or changes.This study will contribute to the discussion whether additional fusion after a cervical laminectomy results in a better clinical outcome.ISRCT NUMBER: ISRCTN72800446.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. r.bartels@nch.umcn.nl

ABSTRACT

Background: laminectomy is a valuable surgical treatment for some patients with a cervical radiculomyelopathy due to cervical spinal stenosis. More recently attention has been given to motion of the spinal cord over spondylotic spurs as a cause of myelopathic changes. Immobilisation by fusion could have a positive effect on the recovery of myelopathic signs or changes. This has never been investigated in a prospective, randomised trial. Lamifuse is an acronyme for laminectomy and fusion.

Methods/design: Lamifuse is a multicentre, randomised controlled trial comparing laminectomy with and without fusion in patients with a symptomatic cervical canal stenosis. The study population will be enrolled from patients that are 60 years or older with myelopathic signs and/or symptoms due to a cervical canal stenosis. A kyphotis shape of the cervical spine is an exclusion criterium. Each treatment arm needs 30 patients.

Discussion: This study will contribute to the discussion whether additional fusion after a cervical laminectomy results in a better clinical outcome. ISRCT NUMBER: ISRCTN72800446.

Show MeSH
Related in: MedlinePlus