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Three papers report on new components involved in fission of the budding yeast mitochondrial outer membrane... In the absence of Dnm1p, some Gag3p/Mdv1p is associated with mitochondria, but it is no longer in punctate structures... Mozdy et al. and Tieu and Nunnari find that, without Fis1p, some Dnm1p and Gag3p/Mdv1p still find their way to mitochondria, although they end up in just a few large clumps... Without both Fis1p and Dnm1p, mitochondrial localization of Gag3p/Mdv1p is lost completely... Fis1p may both distribute and activate the Dnm1p complex, with Gag3p/Mdv1p making a later, Dnm1p-dependent appearance... The modified Apg8p is released from membranes by a second cleavage by Apg4p... Kirisako et al. suggest that modified Apg8p, which is present on premature autophagosomes, may bring in components necessary for autophagosome assembly before it is subsequently removed by Apg4p.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Three papers report on new components involved in fission of the budding yeast mitochondrial outer membrane... In the absence of Dnm1p, some Gag3p/Mdv1p is associated with mitochondria, but it is no longer in punctate structures... Mozdy et al. and Tieu and Nunnari find that, without Fis1p, some Dnm1p and Gag3p/Mdv1p still find their way to mitochondria, although they end up in just a few large clumps... Without both Fis1p and Dnm1p, mitochondrial localization of Gag3p/Mdv1p is lost completely... Fis1p may both distribute and activate the Dnm1p complex, with Gag3p/Mdv1p making a later, Dnm1p-dependent appearance... The modified Apg8p is released from membranes by a second cleavage by Apg4p... Kirisako et al. suggest that modified Apg8p, which is present on premature autophagosomes, may bring in components necessary for autophagosome assembly before it is subsequently removed by Apg4p.

No MeSH data available.