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Dimitroff et al. (page 1277) appear to have uncovered the major “homing receptor” that allows hematopoietic progenitor cells (HPCs) to enter bone marrow... The discovery of the receptor, a novel glycoform of CD44, could form the basis for improvements in HPC selection for hematopoietic stem cell transplants... Moore et al. (page 1199) identify a C. elegans homologue of the mammalian kinetochore structural component CENP-C; the same group had previously found worm homologues of CENP-F and the histone H3 variant CENP-A... In addition, depleting the C. elegans homologue of the INCENP chromosomal passenger protein causes mitotic chromosome segregation defects that differ from those seen during CENP-A or CENP-C depletion, indicating that kinetochore assembly is independent of INCENP recruitment... By electron microscopy with high-pressure freezing followed by freeze substitution, Howe et al. (page 1227) demonstrate that the kinetochore in mitotic and meiotic C. elegans cells is similar to the mammalian kinetochore... The results suggest that cells normally use a ROCK-dependent mechanism to create contractile force, which, in combination with an mDia1-dependent input, causes focal complexes to grow... In this model, focal contacts act as mechanosensors to determine the local balance between cell-generated force and extracellular matrix rigidity.

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Dimitroff et al. (page 1277) appear to have uncovered the major “homing receptor” that allows hematopoietic progenitor cells (HPCs) to enter bone marrow... The discovery of the receptor, a novel glycoform of CD44, could form the basis for improvements in HPC selection for hematopoietic stem cell transplants... Moore et al. (page 1199) identify a C. elegans homologue of the mammalian kinetochore structural component CENP-C; the same group had previously found worm homologues of CENP-F and the histone H3 variant CENP-A... In addition, depleting the C. elegans homologue of the INCENP chromosomal passenger protein causes mitotic chromosome segregation defects that differ from those seen during CENP-A or CENP-C depletion, indicating that kinetochore assembly is independent of INCENP recruitment... By electron microscopy with high-pressure freezing followed by freeze substitution, Howe et al. (page 1227) demonstrate that the kinetochore in mitotic and meiotic C. elegans cells is similar to the mammalian kinetochore... The results suggest that cells normally use a ROCK-dependent mechanism to create contractile force, which, in combination with an mDia1-dependent input, causes focal complexes to grow... In this model, focal contacts act as mechanosensors to determine the local balance between cell-generated force and extracellular matrix rigidity.

No MeSH data available.