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Movement in Colorado: the Keystone Symposium on Cell Migration and Invasion. Breckenridge, CO: January 18-23, 2003.

Wells WA - J. Cell Biol. (2003)

Bottom Line: The use of complex and three-dimensional environments, plus the promise of collaborative work by a Migration Consortium, are heating up research into cell migration.

View Article: PubMed Central - PubMed

Affiliation: wellsw@rockefeller.edu

ABSTRACT
The use of complex and three-dimensional environments, plus the promise of collaborative work by a Migration Consortium, are heating up research into cell migration.

Show MeSH
Polymerization of a web of actin drives forward movement of a fish keratocyte.Svitkina
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Related In: Results  -  Collection


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fig1: Polymerization of a web of actin drives forward movement of a fish keratocyte.Svitkina

Mentions: Actin polymerization drives cells forward (Fig. 1). The canonical version of this mechanism was put forward by Tom Pollard (Yale University, New Haven, CT) in his keynote address. Pollard outlined the dendritic nucleation model (Mullins et al., 1998; Svitkina and Borisy, 1999), in which the actin-nucleating Arp2/3 complex binds to the side of existing actin filaments to make branched structures that elongate toward the front of the cell. Further back, cofilin severs and debranches these filaments—in the latter case by promoting the dissociation of phosphate from actin, thus causing the branch to dissociate from the Arp2/3 complex (Blanchoin et al., 2000).


Movement in Colorado: the Keystone Symposium on Cell Migration and Invasion. Breckenridge, CO: January 18-23, 2003.

Wells WA - J. Cell Biol. (2003)

Polymerization of a web of actin drives forward movement of a fish keratocyte.Svitkina
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2172756&req=5

fig1: Polymerization of a web of actin drives forward movement of a fish keratocyte.Svitkina
Mentions: Actin polymerization drives cells forward (Fig. 1). The canonical version of this mechanism was put forward by Tom Pollard (Yale University, New Haven, CT) in his keynote address. Pollard outlined the dendritic nucleation model (Mullins et al., 1998; Svitkina and Borisy, 1999), in which the actin-nucleating Arp2/3 complex binds to the side of existing actin filaments to make branched structures that elongate toward the front of the cell. Further back, cofilin severs and debranches these filaments—in the latter case by promoting the dissociation of phosphate from actin, thus causing the branch to dissociate from the Arp2/3 complex (Blanchoin et al., 2000).

Bottom Line: The use of complex and three-dimensional environments, plus the promise of collaborative work by a Migration Consortium, are heating up research into cell migration.

View Article: PubMed Central - PubMed

Affiliation: wellsw@rockefeller.edu

ABSTRACT
The use of complex and three-dimensional environments, plus the promise of collaborative work by a Migration Consortium, are heating up research into cell migration.

Show MeSH