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Patterned by adhesion

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Elaborate tissue patterns are formed by two cell types with complementary adhesion molecules, as revealed by Sujin Bao and Ross Cagan (Washington University, St. Louis, MO)... We can make kidney cells [in vitro], but how do you sort them into a glomerulus? What we really want to know is not what makes a lung cell, but what makes a lung. ” A hint came when others found that mutation of the Ig family member Roughest caused disorganized ommatidia in flies but did not affect cell fate... IPCs expressed Roughest, while the ommatidia expressed its homologue, Hibris... Roughest bound more strongly to Hibris than to itself, thus creating competition between IPCs for contact with ommatidia and minimizing interactions between IPCs... The result is that “the IPCs stretch out between the ommatidia,” says Cagan. “The lowest free energy shape they can take is a hexagon. ” Heterophilic interactions led to the formation of lasting junctions between the two cell types... IPCs that lost out in the competition for contact with ommatidia died by apoptosis; Roughest expression level was a determining factor in survival versus death... An IPC that had extra Roughest often inhabited a niche normally occupied by two IPCs... Deletion of Roughest from an IPC, by contrast, increased that cell's chance of dying... As mammalian homologues of Roughest are strongly expressed in the kidneys, Cagan suspects that they are also a driving force behind glomerulus formation. “The way you can get a complex refined structure,” he says, “is to use a two-piece system and then control the expression of those two pieces. ” Reference:

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IPC (green) movements and patterning are disturbed in a Roughest mutant (right).CAGAN/ELSEVIER
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uro1: IPC (green) movements and patterning are disturbed in a Roughest mutant (right).CAGAN/ELSEVIER


Patterned by adhesion
IPC (green) movements and patterning are disturbed in a Roughest mutant (right).CAGAN/ELSEVIER
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2171374&req=5

uro1: IPC (green) movements and patterning are disturbed in a Roughest mutant (right).CAGAN/ELSEVIER

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Elaborate tissue patterns are formed by two cell types with complementary adhesion molecules, as revealed by Sujin Bao and Ross Cagan (Washington University, St. Louis, MO)... We can make kidney cells [in vitro], but how do you sort them into a glomerulus? What we really want to know is not what makes a lung cell, but what makes a lung. ” A hint came when others found that mutation of the Ig family member Roughest caused disorganized ommatidia in flies but did not affect cell fate... IPCs expressed Roughest, while the ommatidia expressed its homologue, Hibris... Roughest bound more strongly to Hibris than to itself, thus creating competition between IPCs for contact with ommatidia and minimizing interactions between IPCs... The result is that “the IPCs stretch out between the ommatidia,” says Cagan. “The lowest free energy shape they can take is a hexagon. ” Heterophilic interactions led to the formation of lasting junctions between the two cell types... IPCs that lost out in the competition for contact with ommatidia died by apoptosis; Roughest expression level was a determining factor in survival versus death... An IPC that had extra Roughest often inhabited a niche normally occupied by two IPCs... Deletion of Roughest from an IPC, by contrast, increased that cell's chance of dying... As mammalian homologues of Roughest are strongly expressed in the kidneys, Cagan suspects that they are also a driving force behind glomerulus formation. “The way you can get a complex refined structure,” he says, “is to use a two-piece system and then control the expression of those two pieces. ” Reference:

No MeSH data available.