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Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats.

Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK - J Clin Biochem Nutr (2007)

Bottom Line: The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol.Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents.The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata - 700 020, India.

ABSTRACT
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.

No MeSH data available.


Related in: MedlinePlus

The effect of drugs on mucin level of ulcerated rats. Stomach ulceration in rats was induced by oral administration of indomethacin (30 mg/kg body weight). The drugs at the doses mentioned in the Materials and methods section were administered 4 h after indomethacin administration. The mucin assay was carried out after 7 days for all the samples except for the ulcerated control. The assay for the ulcerated control was carried out 4 h after indomethacin administration. 1: normal control; 2: ulcerated control; 3: ulcerated PBE treated; 4: ulcerated EOE treated; 5: ulcerated TCE treated; 6: ulcerated TBE treated; 7: ulcerated misoprostol treated. The values are mean ± SEM and were compared statistically by one-way ANOVA. *Significant at p<0.05 as compared to the zero day experimental control rats (group II). The values with the groups III, IV and VII were significantly different from that of the groups V–VI (p<0.05) without being significantly different from each other.
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Figure 2: The effect of drugs on mucin level of ulcerated rats. Stomach ulceration in rats was induced by oral administration of indomethacin (30 mg/kg body weight). The drugs at the doses mentioned in the Materials and methods section were administered 4 h after indomethacin administration. The mucin assay was carried out after 7 days for all the samples except for the ulcerated control. The assay for the ulcerated control was carried out 4 h after indomethacin administration. 1: normal control; 2: ulcerated control; 3: ulcerated PBE treated; 4: ulcerated EOE treated; 5: ulcerated TCE treated; 6: ulcerated TBE treated; 7: ulcerated misoprostol treated. The values are mean ± SEM and were compared statistically by one-way ANOVA. *Significant at p<0.05 as compared to the zero day experimental control rats (group II). The values with the groups III, IV and VII were significantly different from that of the groups V–VI (p<0.05) without being significantly different from each other.

Mentions: Indomethacin administration to rats decreased defensive mucin secretion significantly as indicated by decrease in the contents of Alcian blue-binding protein (43.5% decrease, p<0.05) and mucosal glycoproteins (76.4% decrease, p<0.05) in the ulcerated rats of group II compared to those in unulcerated rats (group I). Treatment with PBE and EOE enhanced tissue mucin levels to those in normal unulcerated rats, while the mucosal glycoprotein content was also increased to 65 and 61% of the normal value respectively. Surprisingly, treatment with TCE or TBE had no effect on the mucin level. Further, although TBE marginally improved the hexosamine level to ~34% of the normal value, TCE did not augment it. The results on the levels of mucin and hexosamine are summarized in Fig. 2 and Fig. 3 respectively. The augmentation of mucin levels by PBE and EOE were significant (p<0.05) as compared to untreated ulcerated controls (group II). Misoprostol also increased the mucin secretion and mucosal glycoproteins in the ulcerated rats to 94 and 90% of the normal values.


Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats.

Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK - J Clin Biochem Nutr (2007)

The effect of drugs on mucin level of ulcerated rats. Stomach ulceration in rats was induced by oral administration of indomethacin (30 mg/kg body weight). The drugs at the doses mentioned in the Materials and methods section were administered 4 h after indomethacin administration. The mucin assay was carried out after 7 days for all the samples except for the ulcerated control. The assay for the ulcerated control was carried out 4 h after indomethacin administration. 1: normal control; 2: ulcerated control; 3: ulcerated PBE treated; 4: ulcerated EOE treated; 5: ulcerated TCE treated; 6: ulcerated TBE treated; 7: ulcerated misoprostol treated. The values are mean ± SEM and were compared statistically by one-way ANOVA. *Significant at p<0.05 as compared to the zero day experimental control rats (group II). The values with the groups III, IV and VII were significantly different from that of the groups V–VI (p<0.05) without being significantly different from each other.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2170955&req=5

Figure 2: The effect of drugs on mucin level of ulcerated rats. Stomach ulceration in rats was induced by oral administration of indomethacin (30 mg/kg body weight). The drugs at the doses mentioned in the Materials and methods section were administered 4 h after indomethacin administration. The mucin assay was carried out after 7 days for all the samples except for the ulcerated control. The assay for the ulcerated control was carried out 4 h after indomethacin administration. 1: normal control; 2: ulcerated control; 3: ulcerated PBE treated; 4: ulcerated EOE treated; 5: ulcerated TCE treated; 6: ulcerated TBE treated; 7: ulcerated misoprostol treated. The values are mean ± SEM and were compared statistically by one-way ANOVA. *Significant at p<0.05 as compared to the zero day experimental control rats (group II). The values with the groups III, IV and VII were significantly different from that of the groups V–VI (p<0.05) without being significantly different from each other.
Mentions: Indomethacin administration to rats decreased defensive mucin secretion significantly as indicated by decrease in the contents of Alcian blue-binding protein (43.5% decrease, p<0.05) and mucosal glycoproteins (76.4% decrease, p<0.05) in the ulcerated rats of group II compared to those in unulcerated rats (group I). Treatment with PBE and EOE enhanced tissue mucin levels to those in normal unulcerated rats, while the mucosal glycoprotein content was also increased to 65 and 61% of the normal value respectively. Surprisingly, treatment with TCE or TBE had no effect on the mucin level. Further, although TBE marginally improved the hexosamine level to ~34% of the normal value, TCE did not augment it. The results on the levels of mucin and hexosamine are summarized in Fig. 2 and Fig. 3 respectively. The augmentation of mucin levels by PBE and EOE were significant (p<0.05) as compared to untreated ulcerated controls (group II). Misoprostol also increased the mucin secretion and mucosal glycoproteins in the ulcerated rats to 94 and 90% of the normal values.

Bottom Line: The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol.Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents.The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata - 700 020, India.

ABSTRACT
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.

No MeSH data available.


Related in: MedlinePlus