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Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats.

Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK - J Clin Biochem Nutr (2007)

Bottom Line: The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol.Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents.The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata - 700 020, India.

ABSTRACT
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.

No MeSH data available.


Related in: MedlinePlus

Macroscopic assessment of the healing of acute gastric mucosal injury induced by indomethacin in rats and its prevention by PBE, EOE and misoprostol. Section of rat stomachs obtained from a: normal control rats; b: ulcerated untreated control rats 4 h after indomethacin administration; c: ulcerated untreated control rats 7 day after indomethacin administration; d: ulcerated rats treated with PBE for 7 days; e: ulcerated rats treated with PBE for 7 days; f: ulcerated rats treated with misoprotsol for 7 days.
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Figure 1: Macroscopic assessment of the healing of acute gastric mucosal injury induced by indomethacin in rats and its prevention by PBE, EOE and misoprostol. Section of rat stomachs obtained from a: normal control rats; b: ulcerated untreated control rats 4 h after indomethacin administration; c: ulcerated untreated control rats 7 day after indomethacin administration; d: ulcerated rats treated with PBE for 7 days; e: ulcerated rats treated with PBE for 7 days; f: ulcerated rats treated with misoprotsol for 7 days.

Mentions: The gastric tissue morphologies of the rats of groups I–V and VIII were also observed macroscopically (Fig. 1a–f). This revealed that compared to the vehicle treated rats, oral administration of indomethacin (30 mg/kg) produced acute lesions in the gastric mucosa within 4 h with number of blood clots in the ulcer spots and perforations (cf. Fig. 1a, b). The seven day ulcerated (untreated experimental control) stomach showed lesser spots but the tissues were hyaline in nature (Fig. 1c). In comparison, stomachs of the PBE and EOE-treated rats were healthy almost without any ulcer spots (Fig. 1d, e). The stomachs of the rats treated with PBE were equivalent to those of the normal control rats (group I) (cf. Fig. 1d, a). In comparison, stomachs of the rats treated with misoprostol showed less ulcer spots but the tissues remained hyaline in nature (Fig. 1f).


Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats.

Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK - J Clin Biochem Nutr (2007)

Macroscopic assessment of the healing of acute gastric mucosal injury induced by indomethacin in rats and its prevention by PBE, EOE and misoprostol. Section of rat stomachs obtained from a: normal control rats; b: ulcerated untreated control rats 4 h after indomethacin administration; c: ulcerated untreated control rats 7 day after indomethacin administration; d: ulcerated rats treated with PBE for 7 days; e: ulcerated rats treated with PBE for 7 days; f: ulcerated rats treated with misoprotsol for 7 days.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2170955&req=5

Figure 1: Macroscopic assessment of the healing of acute gastric mucosal injury induced by indomethacin in rats and its prevention by PBE, EOE and misoprostol. Section of rat stomachs obtained from a: normal control rats; b: ulcerated untreated control rats 4 h after indomethacin administration; c: ulcerated untreated control rats 7 day after indomethacin administration; d: ulcerated rats treated with PBE for 7 days; e: ulcerated rats treated with PBE for 7 days; f: ulcerated rats treated with misoprotsol for 7 days.
Mentions: The gastric tissue morphologies of the rats of groups I–V and VIII were also observed macroscopically (Fig. 1a–f). This revealed that compared to the vehicle treated rats, oral administration of indomethacin (30 mg/kg) produced acute lesions in the gastric mucosa within 4 h with number of blood clots in the ulcer spots and perforations (cf. Fig. 1a, b). The seven day ulcerated (untreated experimental control) stomach showed lesser spots but the tissues were hyaline in nature (Fig. 1c). In comparison, stomachs of the PBE and EOE-treated rats were healthy almost without any ulcer spots (Fig. 1d, e). The stomachs of the rats treated with PBE were equivalent to those of the normal control rats (group I) (cf. Fig. 1d, a). In comparison, stomachs of the rats treated with misoprostol showed less ulcer spots but the tissues remained hyaline in nature (Fig. 1f).

Bottom Line: The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol.Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents.The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata - 700 020, India.

ABSTRACT
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.

No MeSH data available.


Related in: MedlinePlus