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The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan.

Kettawan A, Kunthida C, Takahashi T, Kishi T, Chikazawa J, Sakata Y, Yano E, Watabe K, Yamamoto Y, Okamoto T - J Clin Biochem Nutr (2007)

Bottom Line: We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely.Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector.From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10).

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Biochemistry, Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.

ABSTRACT
Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements.

No MeSH data available.


Related in: MedlinePlus

H2CoQ10 produced by interaction of CoQ10 with vitamins C and/or E in soft capsule and liquid. Each formula is shown in Table 1.
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Related In: Results  -  Collection


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Figure 2: H2CoQ10 produced by interaction of CoQ10 with vitamins C and/or E in soft capsule and liquid. Each formula is shown in Table 1.

Mentions: As shown in Fig. 2, co-existence of CoQ10 and vitamin E and/or vitamin C produced reduction of CoQ10 to H2CoQ10 in SCPs and a LQ. The content ratio of vitamin E to CoQ10 was also important. The existence of safflower oil in SCPs was also an essential condition for production of H2CoQ10 from CoQ10 in SCPs. In particular, a LQ form of CoQ10 that co-existed with vitamin E and vitamin C exhibited a high ratio of the reduced form to total CoQ10 in a time-dependent manner. In an HCP, however, the reduction of CoQ10 to H2CoQ10 was not observed even if CoQ10 co-existed with vitamin E and C.


The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan.

Kettawan A, Kunthida C, Takahashi T, Kishi T, Chikazawa J, Sakata Y, Yano E, Watabe K, Yamamoto Y, Okamoto T - J Clin Biochem Nutr (2007)

H2CoQ10 produced by interaction of CoQ10 with vitamins C and/or E in soft capsule and liquid. Each formula is shown in Table 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2170950&req=5

Figure 2: H2CoQ10 produced by interaction of CoQ10 with vitamins C and/or E in soft capsule and liquid. Each formula is shown in Table 1.
Mentions: As shown in Fig. 2, co-existence of CoQ10 and vitamin E and/or vitamin C produced reduction of CoQ10 to H2CoQ10 in SCPs and a LQ. The content ratio of vitamin E to CoQ10 was also important. The existence of safflower oil in SCPs was also an essential condition for production of H2CoQ10 from CoQ10 in SCPs. In particular, a LQ form of CoQ10 that co-existed with vitamin E and vitamin C exhibited a high ratio of the reduced form to total CoQ10 in a time-dependent manner. In an HCP, however, the reduction of CoQ10 to H2CoQ10 was not observed even if CoQ10 co-existed with vitamin E and C.

Bottom Line: We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely.Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector.From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10).

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Biochemistry, Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.

ABSTRACT
Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements.

No MeSH data available.


Related in: MedlinePlus