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The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan.

Kettawan A, Kunthida C, Takahashi T, Kishi T, Chikazawa J, Sakata Y, Yano E, Watabe K, Yamamoto Y, Okamoto T - J Clin Biochem Nutr (2007)

Bottom Line: We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely.Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector.From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10).

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Biochemistry, Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.

ABSTRACT
Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements.

No MeSH data available.


Related in: MedlinePlus

Internal appearance of soft capsule forms of CoQ10-supplements. (A) Crystallized CoQ10; the yellowed compound is crystallized CoQ10. (B) Typical soft capsule appearance; CoQ10 distributes uniformly in the soft capsule.
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Figure 1: Internal appearance of soft capsule forms of CoQ10-supplements. (A) Crystallized CoQ10; the yellowed compound is crystallized CoQ10. (B) Typical soft capsule appearance; CoQ10 distributes uniformly in the soft capsule.

Mentions: First, we assessed the internal profile of different SCP CoQ10 supplement products. Most samples showed the typical internal profile of SCPs. However, as shown in Fig. 1, in a few SCPs, CoQ10 crystallized itself inside and existed in the solid state but not the lipid-soluble form. Moreover, a certain SCP did not show the uniform distribution of CoQ10 in the capsule.


The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan.

Kettawan A, Kunthida C, Takahashi T, Kishi T, Chikazawa J, Sakata Y, Yano E, Watabe K, Yamamoto Y, Okamoto T - J Clin Biochem Nutr (2007)

Internal appearance of soft capsule forms of CoQ10-supplements. (A) Crystallized CoQ10; the yellowed compound is crystallized CoQ10. (B) Typical soft capsule appearance; CoQ10 distributes uniformly in the soft capsule.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2170950&req=5

Figure 1: Internal appearance of soft capsule forms of CoQ10-supplements. (A) Crystallized CoQ10; the yellowed compound is crystallized CoQ10. (B) Typical soft capsule appearance; CoQ10 distributes uniformly in the soft capsule.
Mentions: First, we assessed the internal profile of different SCP CoQ10 supplement products. Most samples showed the typical internal profile of SCPs. However, as shown in Fig. 1, in a few SCPs, CoQ10 crystallized itself inside and existed in the solid state but not the lipid-soluble form. Moreover, a certain SCP did not show the uniform distribution of CoQ10 in the capsule.

Bottom Line: We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely.Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector.From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10).

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Biochemistry, Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.

ABSTRACT
Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements.

No MeSH data available.


Related in: MedlinePlus