Limits...
Secondary breast lymphoma diagnosed by vacuum-assisted breast biopsy: a case report.

Zagouri F, Sergentanis TN, Nonni A, Koulocheri D, Domeyer P, Dardamanis D, Michalopoulos NV, Pararas N, Gounaris A, Zografos GC - J Med Case Rep (2007)

Bottom Line: VABB yielded enough tissue for immunohistochemistry/WHO classification.It should be stressed that VABB was able to yield enough tissue for WHO classification.In general, lymphoma should never be omitted in the differential diagnosis, since no pathognomonic radiologic findings exist for its diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens; 114, Vas Sofias Ave, Athens 116 27, Greece. gzografo@med.uoa.gr.

ABSTRACT

Introduction: Breast lymphoma, either as a manifestation of primary extranodal disease or as secondary involvement, is a rare malignancy, and its diagnosis, prognosis, and treatment have not been clearly defined. On the other hand, Vacuum-assisted breast biopsy (VABB) is a minimally invasive technique with ever-growing use for the diagnosis of mammographically detected, non-palpable breast lesions.

Case presentation: A symptom-free, 56-year-old woman presented with a non-palpable BI-RADS 4B lesion without microcalcifications. She had a positive family history for breast cancer and a history of atypical ductal hyperplasia in the ipsilateral breast four years ago. She reported having been treated for non-Hodgkin lymphoma 12 years ago. With the suspicion of breast cancer, mammographically guided VABB with 11-gauge probe (on the stereotactic Fisher's table) was performed. VABB made the diagnosis of a non-Hodgkin, grade II, B-cell germinal-center lymphoma. VABB yielded enough tissue for immunohistochemistry/WHO classification.

Conclusion: This is the first case in the literature demonstrating the successful diagnosis of breast lymphoma by VABB, irrespectively of the level of clinical suspicion. It should be stressed that VABB was able to yield enough tissue for WHO classification. In general, lymphoma should never be omitted in the differential diagnosis, since no pathognomonic radiologic findings exist for its diagnosis.

No MeSH data available.


Related in: MedlinePlus

Invasion of the breast parenchyma by the nodular non-Hodgkin B-cell lymphoma (H+E × 100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2169247&req=5

Figure 4: Invasion of the breast parenchyma by the nodular non-Hodgkin B-cell lymphoma (H+E × 100).

Mentions: According to the pathological examination, the lesion was a non-Hodgkin, grade II, germinal-center lymphoma of B-cell origin and exhibited a nodular pattern (> 75%) (Figure 4). More specifically, the nodules were formed by cells with morphology of centroblasts and centrocytes; the number of centroblasts did not exceed 15 per optical field (×40). The stroma exhibited hyalinization where the malignant lymphoid tissue was present. The malignant lymphoid cells were occasionally present within the fatty breast tissue, and a few entrapped mammary ducts were recognized within the sclerotic stroma. Immunohistochemically, the lymphoid cells were positive for CD20, bcl-2 (Figure 5) and CD10, whereas some CD10-positive cells were present outside the nodules. There was indication of kappa chain clonality. The Ki-67 proliferation marker was positive in 10% of cells.


Secondary breast lymphoma diagnosed by vacuum-assisted breast biopsy: a case report.

Zagouri F, Sergentanis TN, Nonni A, Koulocheri D, Domeyer P, Dardamanis D, Michalopoulos NV, Pararas N, Gounaris A, Zografos GC - J Med Case Rep (2007)

Invasion of the breast parenchyma by the nodular non-Hodgkin B-cell lymphoma (H+E × 100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2169247&req=5

Figure 4: Invasion of the breast parenchyma by the nodular non-Hodgkin B-cell lymphoma (H+E × 100).
Mentions: According to the pathological examination, the lesion was a non-Hodgkin, grade II, germinal-center lymphoma of B-cell origin and exhibited a nodular pattern (> 75%) (Figure 4). More specifically, the nodules were formed by cells with morphology of centroblasts and centrocytes; the number of centroblasts did not exceed 15 per optical field (×40). The stroma exhibited hyalinization where the malignant lymphoid tissue was present. The malignant lymphoid cells were occasionally present within the fatty breast tissue, and a few entrapped mammary ducts were recognized within the sclerotic stroma. Immunohistochemically, the lymphoid cells were positive for CD20, bcl-2 (Figure 5) and CD10, whereas some CD10-positive cells were present outside the nodules. There was indication of kappa chain clonality. The Ki-67 proliferation marker was positive in 10% of cells.

Bottom Line: VABB yielded enough tissue for immunohistochemistry/WHO classification.It should be stressed that VABB was able to yield enough tissue for WHO classification.In general, lymphoma should never be omitted in the differential diagnosis, since no pathognomonic radiologic findings exist for its diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens; 114, Vas Sofias Ave, Athens 116 27, Greece. gzografo@med.uoa.gr.

ABSTRACT

Introduction: Breast lymphoma, either as a manifestation of primary extranodal disease or as secondary involvement, is a rare malignancy, and its diagnosis, prognosis, and treatment have not been clearly defined. On the other hand, Vacuum-assisted breast biopsy (VABB) is a minimally invasive technique with ever-growing use for the diagnosis of mammographically detected, non-palpable breast lesions.

Case presentation: A symptom-free, 56-year-old woman presented with a non-palpable BI-RADS 4B lesion without microcalcifications. She had a positive family history for breast cancer and a history of atypical ductal hyperplasia in the ipsilateral breast four years ago. She reported having been treated for non-Hodgkin lymphoma 12 years ago. With the suspicion of breast cancer, mammographically guided VABB with 11-gauge probe (on the stereotactic Fisher's table) was performed. VABB made the diagnosis of a non-Hodgkin, grade II, B-cell germinal-center lymphoma. VABB yielded enough tissue for immunohistochemistry/WHO classification.

Conclusion: This is the first case in the literature demonstrating the successful diagnosis of breast lymphoma by VABB, irrespectively of the level of clinical suspicion. It should be stressed that VABB was able to yield enough tissue for WHO classification. In general, lymphoma should never be omitted in the differential diagnosis, since no pathognomonic radiologic findings exist for its diagnosis.

No MeSH data available.


Related in: MedlinePlus