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Continuous negative extrathoracic pressure combined with high-frequency oscillation improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in a rabbit model of surfactant depletion.

Naito S, Hiroma T, Nakamura T - Biomed Eng Online (2007)

Bottom Line: Negative air pressure ventilation has been used to maintain adequate functional residual capacity in patients with chronic muscular disease and to decrease transpulmonary pressure and improve cardiac output during right heart surgery.Physiological and blood gas data were compared among groups using analysis of variance.Group 1 showed significantly higher oxygenation than Group 2, and the same oxygenation with significantly higher mean blood pressure compared to Group 3.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Neonatology, Nagano Children's Hospital, Nagano, Japan. tnakamura@naganoch.gr.jp

ABSTRACT

Background: Negative air pressure ventilation has been used to maintain adequate functional residual capacity in patients with chronic muscular disease and to decrease transpulmonary pressure and improve cardiac output during right heart surgery. High-frequency oscillation (HFO) exerts beneficial effects on gas exchange in neonates with acute respiratory failure. We examined whether continuous negative extrathoracic pressure (CNEP) combined with HFO would be effective for treating acute respiratory failure in an animal model.

Methods: The effects of CNEP combined with HFO on pulmonary gas exchange and circulation were examined in a surfactant-depleted rabbit model. After induction of severe lung injury by repeated saline lung lavage, 18 adult white Japanese rabbits were randomly assigned to 3 groups: Group 1, CNEP (extra thoracic negative pressure, -10 cmH2O) with HFO (mean airway pressure (MAP), 10 cmH2O); Group 2, HFO (MAP, 10 cmH2O); and Group 3, HFO (MAP, 15 cmH2O). Physiological and blood gas data were compared among groups using analysis of variance.

Results: Group 1 showed significantly higher oxygenation than Group 2, and the same oxygenation with significantly higher mean blood pressure compared to Group 3.

Conclusion: Adequate CNEP combined with HFO improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in an animal model of respiratory failure.

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Related in: MedlinePlus

Changes in mean arterial pressure. (Diamond) Group 1: CNEP (-10 cmH2O) with low-MAP (10 cmH2O) HFO. (Circle) Group 2: Low-MAP (10 cmH2O) HFO. (Square) Group 3: High-MAP (15 cmH2O) HFO. *p < 0.05 Group 1 vs. Group 3.
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Figure 2: Changes in mean arterial pressure. (Diamond) Group 1: CNEP (-10 cmH2O) with low-MAP (10 cmH2O) HFO. (Circle) Group 2: Low-MAP (10 cmH2O) HFO. (Square) Group 3: High-MAP (15 cmH2O) HFO. *p < 0.05 Group 1 vs. Group 3.

Mentions: Baseline and post-injury data were similar in all 3 groups. Changes in PaO2 over time are shown in Figure 1. In Group 1 (-10 cmH2O CNEP with HFO; MAP 10 cmH2O), PaO2 increased after starting CNEP and was significantly higher than in Group 2 (HFO; MAP, 15 cmH2O) (p < 0.05). Group 3 (HFO; MAP 15 cmH2O) displayed similar PaO2 to Group 1. Changes in MAP during the observation period are shown in Figure 2. Mean arterial pressure was significantly lower in Group 3 than in Group 1 (p < 0.05) throughout the experimental period.


Continuous negative extrathoracic pressure combined with high-frequency oscillation improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in a rabbit model of surfactant depletion.

Naito S, Hiroma T, Nakamura T - Biomed Eng Online (2007)

Changes in mean arterial pressure. (Diamond) Group 1: CNEP (-10 cmH2O) with low-MAP (10 cmH2O) HFO. (Circle) Group 2: Low-MAP (10 cmH2O) HFO. (Square) Group 3: High-MAP (15 cmH2O) HFO. *p < 0.05 Group 1 vs. Group 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2169239&req=5

Figure 2: Changes in mean arterial pressure. (Diamond) Group 1: CNEP (-10 cmH2O) with low-MAP (10 cmH2O) HFO. (Circle) Group 2: Low-MAP (10 cmH2O) HFO. (Square) Group 3: High-MAP (15 cmH2O) HFO. *p < 0.05 Group 1 vs. Group 3.
Mentions: Baseline and post-injury data were similar in all 3 groups. Changes in PaO2 over time are shown in Figure 1. In Group 1 (-10 cmH2O CNEP with HFO; MAP 10 cmH2O), PaO2 increased after starting CNEP and was significantly higher than in Group 2 (HFO; MAP, 15 cmH2O) (p < 0.05). Group 3 (HFO; MAP 15 cmH2O) displayed similar PaO2 to Group 1. Changes in MAP during the observation period are shown in Figure 2. Mean arterial pressure was significantly lower in Group 3 than in Group 1 (p < 0.05) throughout the experimental period.

Bottom Line: Negative air pressure ventilation has been used to maintain adequate functional residual capacity in patients with chronic muscular disease and to decrease transpulmonary pressure and improve cardiac output during right heart surgery.Physiological and blood gas data were compared among groups using analysis of variance.Group 1 showed significantly higher oxygenation than Group 2, and the same oxygenation with significantly higher mean blood pressure compared to Group 3.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Neonatology, Nagano Children's Hospital, Nagano, Japan. tnakamura@naganoch.gr.jp

ABSTRACT

Background: Negative air pressure ventilation has been used to maintain adequate functional residual capacity in patients with chronic muscular disease and to decrease transpulmonary pressure and improve cardiac output during right heart surgery. High-frequency oscillation (HFO) exerts beneficial effects on gas exchange in neonates with acute respiratory failure. We examined whether continuous negative extrathoracic pressure (CNEP) combined with HFO would be effective for treating acute respiratory failure in an animal model.

Methods: The effects of CNEP combined with HFO on pulmonary gas exchange and circulation were examined in a surfactant-depleted rabbit model. After induction of severe lung injury by repeated saline lung lavage, 18 adult white Japanese rabbits were randomly assigned to 3 groups: Group 1, CNEP (extra thoracic negative pressure, -10 cmH2O) with HFO (mean airway pressure (MAP), 10 cmH2O); Group 2, HFO (MAP, 10 cmH2O); and Group 3, HFO (MAP, 15 cmH2O). Physiological and blood gas data were compared among groups using analysis of variance.

Results: Group 1 showed significantly higher oxygenation than Group 2, and the same oxygenation with significantly higher mean blood pressure compared to Group 3.

Conclusion: Adequate CNEP combined with HFO improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in an animal model of respiratory failure.

Show MeSH
Related in: MedlinePlus