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Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in pre- versus postmenopausal women.

Deibert P, König D, Vitolins MZ, Landmann U, Frey I, Zahradnik HP, Berg A - Nutr J (2007)

Bottom Line: In premenopausal women 21% of weight loss was attributed to a reduction in lean body mass.Blood pressure, triglycerides, HDL-cholesterol, and glucose improved significantly only in postmenopausal women whereas total cholesterol and LDL-cholesterol were lowered significantly in both groups.Both groups showed comparable weight loss and in postmenopausal women weight loss was associated with a pronounced improvement in metabolic risk factors thereby reducing the prevalence of metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rehabilitation, Prevention and Sports Medicine, Centre for Internal Medicine, University Hospital, Freiburg Germany. peter.deibert@uniklinik-freiburg.de

ABSTRACT

Background: The present study examines changes in body weight, fat mass, metabolic and hormonal parameters in overweight and obese pre- and postmenopausal women who participated in a weight loss intervention.

Methods: Seventy-two subjects were included in the analysis of this single arm study (premenopausal: 22 women, age 43.7 +/- 6.4 years, BMI 31.0 +/- 2.4 kg/m2; postmenopausal: 50 women, age 58.2 +/- 5.1 years, BMI 32.9 +/- 3.7 kg/m2). Weight reduction was achieved by the use of a meal replacement and fat-reduced diet. In addition, from week 6 to 24 participants attended a guided exercise program. Body composition was analyzed with the Bod Pod(R). Blood pressures were taken at every visit and blood was collected at baseline and closeout of the study to evaluate lipids, insulin, cortisol and leptin levels.

Results: BMI, fat mass, waist circumference, systolic blood pressure, triglycerides, glucose, leptin and cortisol were higher in the postmenopausal women at baseline. Both groups achieved a substantial and comparable weight loss (pre- vs. postmenopausal: 6.7 +/- 4.9 vs 6.7 +/- 4.4 kg; n.s.). However, in contrast to premenopausal women, weight loss in postmenopausal women was exclusively due to a reduction of fat mass (-5.3 +/- 5.1 vs -6.6 +/- 4.1 kg; p < 0.01). In premenopausal women 21% of weight loss was attributed to a reduction in lean body mass. Blood pressure, triglycerides, HDL-cholesterol, and glucose improved significantly only in postmenopausal women whereas total cholesterol and LDL-cholesterol were lowered significantly in both groups.

Conclusion: Both groups showed comparable weight loss and in postmenopausal women weight loss was associated with a pronounced improvement in metabolic risk factors thereby reducing the prevalence of metabolic syndrome.

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Related in: MedlinePlus

Comparison of changes after 48 weeks of total cholesterol (ΔTC), triglycerides (ΔTG), HDL-cholesterol (ΔHDL-C), LDL-cholesterol (ΔLDL-C), systolic (ΔBPsys) and diastolic (ΔBPdia) blood pressure and fasting serum glucose (ΔGluc) between pre- and postmenopausal women. * significant changes from baseline within group p < 0.05. ** significant changes from baseline within group p < 0.01.
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Figure 2: Comparison of changes after 48 weeks of total cholesterol (ΔTC), triglycerides (ΔTG), HDL-cholesterol (ΔHDL-C), LDL-cholesterol (ΔLDL-C), systolic (ΔBPsys) and diastolic (ΔBPdia) blood pressure and fasting serum glucose (ΔGluc) between pre- and postmenopausal women. * significant changes from baseline within group p < 0.05. ** significant changes from baseline within group p < 0.01.

Mentions: At closeout, total cholesterol (TC) (-22.9 ± 25.5 mg/dl; p < 0.01) and LDL-cholesterol (LDL-C) (-21.5 ± 19.27 mg/dl; p < 0.01) were markedly lower in the premenopausal women but only slightly so in the postmenopausal women (TC: -8.8 ± 30,7; p < 0.05; LDL-C: -6.6 ± 25.4 mg/dl, p < 0.05). HDL-cholesterol (HDL-C) (+3.43 ± 11.7 mg/dl; p < 0.05), TG (-30.4 ± 53.7 mg/dl; p < 0.01) and fasting glucose levels (Gluc) (-2.6 ± 9.3 mg/dl; p < 0.05) improved significantly only in postmenopausal women. The reductions in TC, TG and Gluc were not significantly different between the groups (Figure 2), however the level for each parameter was still significantly lower in the premenopausal group at the end of the study (p < 0.05).


Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in pre- versus postmenopausal women.

Deibert P, König D, Vitolins MZ, Landmann U, Frey I, Zahradnik HP, Berg A - Nutr J (2007)

Comparison of changes after 48 weeks of total cholesterol (ΔTC), triglycerides (ΔTG), HDL-cholesterol (ΔHDL-C), LDL-cholesterol (ΔLDL-C), systolic (ΔBPsys) and diastolic (ΔBPdia) blood pressure and fasting serum glucose (ΔGluc) between pre- and postmenopausal women. * significant changes from baseline within group p < 0.05. ** significant changes from baseline within group p < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2164948&req=5

Figure 2: Comparison of changes after 48 weeks of total cholesterol (ΔTC), triglycerides (ΔTG), HDL-cholesterol (ΔHDL-C), LDL-cholesterol (ΔLDL-C), systolic (ΔBPsys) and diastolic (ΔBPdia) blood pressure and fasting serum glucose (ΔGluc) between pre- and postmenopausal women. * significant changes from baseline within group p < 0.05. ** significant changes from baseline within group p < 0.01.
Mentions: At closeout, total cholesterol (TC) (-22.9 ± 25.5 mg/dl; p < 0.01) and LDL-cholesterol (LDL-C) (-21.5 ± 19.27 mg/dl; p < 0.01) were markedly lower in the premenopausal women but only slightly so in the postmenopausal women (TC: -8.8 ± 30,7; p < 0.05; LDL-C: -6.6 ± 25.4 mg/dl, p < 0.05). HDL-cholesterol (HDL-C) (+3.43 ± 11.7 mg/dl; p < 0.05), TG (-30.4 ± 53.7 mg/dl; p < 0.01) and fasting glucose levels (Gluc) (-2.6 ± 9.3 mg/dl; p < 0.05) improved significantly only in postmenopausal women. The reductions in TC, TG and Gluc were not significantly different between the groups (Figure 2), however the level for each parameter was still significantly lower in the premenopausal group at the end of the study (p < 0.05).

Bottom Line: In premenopausal women 21% of weight loss was attributed to a reduction in lean body mass.Blood pressure, triglycerides, HDL-cholesterol, and glucose improved significantly only in postmenopausal women whereas total cholesterol and LDL-cholesterol were lowered significantly in both groups.Both groups showed comparable weight loss and in postmenopausal women weight loss was associated with a pronounced improvement in metabolic risk factors thereby reducing the prevalence of metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rehabilitation, Prevention and Sports Medicine, Centre for Internal Medicine, University Hospital, Freiburg Germany. peter.deibert@uniklinik-freiburg.de

ABSTRACT

Background: The present study examines changes in body weight, fat mass, metabolic and hormonal parameters in overweight and obese pre- and postmenopausal women who participated in a weight loss intervention.

Methods: Seventy-two subjects were included in the analysis of this single arm study (premenopausal: 22 women, age 43.7 +/- 6.4 years, BMI 31.0 +/- 2.4 kg/m2; postmenopausal: 50 women, age 58.2 +/- 5.1 years, BMI 32.9 +/- 3.7 kg/m2). Weight reduction was achieved by the use of a meal replacement and fat-reduced diet. In addition, from week 6 to 24 participants attended a guided exercise program. Body composition was analyzed with the Bod Pod(R). Blood pressures were taken at every visit and blood was collected at baseline and closeout of the study to evaluate lipids, insulin, cortisol and leptin levels.

Results: BMI, fat mass, waist circumference, systolic blood pressure, triglycerides, glucose, leptin and cortisol were higher in the postmenopausal women at baseline. Both groups achieved a substantial and comparable weight loss (pre- vs. postmenopausal: 6.7 +/- 4.9 vs 6.7 +/- 4.4 kg; n.s.). However, in contrast to premenopausal women, weight loss in postmenopausal women was exclusively due to a reduction of fat mass (-5.3 +/- 5.1 vs -6.6 +/- 4.1 kg; p < 0.01). In premenopausal women 21% of weight loss was attributed to a reduction in lean body mass. Blood pressure, triglycerides, HDL-cholesterol, and glucose improved significantly only in postmenopausal women whereas total cholesterol and LDL-cholesterol were lowered significantly in both groups.

Conclusion: Both groups showed comparable weight loss and in postmenopausal women weight loss was associated with a pronounced improvement in metabolic risk factors thereby reducing the prevalence of metabolic syndrome.

Show MeSH
Related in: MedlinePlus