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A moving cell needs to make new actin filaments at its ever-advancing leading edge... Alternatively, CARMIL may bind to capping protein on the end of actin filaments and use Arp2/3 to nucleate new actin filaments off those ends... On page 1403, Sabo et al. page 1403, show that APP and the associated protein FE65 cooperate to increase cell movement, as measured in a wound-healing assay... With so much going on during cell movement, Laukaitis et al. (page 1427) have resorted to tracking multiple fluorescent fusion proteins at once... Paxillin, α-actinin, and α5-integrin are recruited to cell adhesions at the leading edge sequentially, thus building a complex that may first become competent to signal, then to act as structural scaffold, and finally to transduce force... This interaction should be sufficient to generate the transverse orientation, as laminin remains transverse under all conditions... The longitudinal orientation of costameres in denervated muscle may be a result of some other underlying muscle structure.

No MeSH data available.


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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A moving cell needs to make new actin filaments at its ever-advancing leading edge... Alternatively, CARMIL may bind to capping protein on the end of actin filaments and use Arp2/3 to nucleate new actin filaments off those ends... On page 1403, Sabo et al. page 1403, show that APP and the associated protein FE65 cooperate to increase cell movement, as measured in a wound-healing assay... With so much going on during cell movement, Laukaitis et al. (page 1427) have resorted to tracking multiple fluorescent fusion proteins at once... Paxillin, α-actinin, and α5-integrin are recruited to cell adhesions at the leading edge sequentially, thus building a complex that may first become competent to signal, then to act as structural scaffold, and finally to transduce force... This interaction should be sufficient to generate the transverse orientation, as laminin remains transverse under all conditions... The longitudinal orientation of costameres in denervated muscle may be a result of some other underlying muscle structure.

No MeSH data available.