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Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction.

Zietkowski Z, Skiepko R, Tomasiak MM, Bodzenta-Lukaszyk A - Respir. Res. (2007)

Bottom Line: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood.No effects of the exercise test on changes in the concentrations of ET-1 in EBC in either asthmatic patients without EIB or healthy volunteers were observed.The release of ET-1 from bronchial epithelium through the influence of many inflammatory cells essential in asthma and interactions with other cytokines, may play an important role in increase of airway inflammation which was observed after postexercise bronchoconstriction in asthmatic patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland. z.zietkowski@wp.pl

ABSTRACT

Background: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood. Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides which play an important role in the development of airway inflammation and remodeling in asthma. The aim of the study was to evaluate the changes in endothelin-1 levels in exhaled breath condensate following intensive exercise in asthmatic patients.

Methods: The study was conducted in a group of 19 asthmatic patients (11 with EIB, 8 without EIB) and 7 healthy volunteers. Changes induced by intensive exercise in the concentrations of endothelin-1 (ET-1) in exhaled breath condensate (EBC) during 24 hours after an exercise challenge test were determined. Moreover, the possible correlations of these measurements with the results of other tests commonly associated with asthma and with the changes of airway inflammation after exercise were observed.

Results: In asthmatic patients with EIB a statistically significant increase in the concentration of ET-1 in EBC collected between 10 minutes and 6 hours after an exercise test was observed. The concentration of ET-1 had returned to its initial level 24 hours after exercise. No effects of the exercise test on changes in the concentrations of ET-1 in EBC in either asthmatic patients without EIB or healthy volunteers were observed. A statistically significant correlation between the maximum increase in ET-1 concentrations in EBC after exercise and either baseline FENO and the increase in FENO or BHR to histamine 24 hours after exercise in the groups of asthmatics with EIB was revealed.

Conclusion: The release of ET-1 from bronchial epithelium through the influence of many inflammatory cells essential in asthma and interactions with other cytokines, may play an important role in increase of airway inflammation which was observed after postexercise bronchoconstriction in asthmatic patients.

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Changes in FENO 24 hours after exercise in the groups of asthmatic patients.
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Figure 2: Changes in FENO 24 hours after exercise in the groups of asthmatic patients.

Mentions: 24 hours after the exercise test, in the group of asthmatics with EIB, a statistically significant increase in FENO (before exercise: 98.90 ppB ± 55.37; 24 hours after exercise: 119.18 ± 64.39; p = 0.034) and BHR to histamine (log PC20FEV1 before exercise: -0.59 mg/ml ± 1.16; 24 hours after exercise: -0.95 ± 1.03; p = 0.0009) was revealed. Figure 2, Figure 3. Such changes were not observed in the group of asthmatic patients without EIB (FENO before exercise: 66.62 ppB ± 23.05; 24 hours after exercise: 67.87 ± 23.03; p = 0.25; log PC20FEV1 before exercise: -0.053 mg/ml ± 0.55; 24 hours after exercise: -0.0511.62 ± 0.59; p = 0.99). In neither group of asthmatics did we detect significant changes in FEV1 24 hours after exercise.


Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction.

Zietkowski Z, Skiepko R, Tomasiak MM, Bodzenta-Lukaszyk A - Respir. Res. (2007)

Changes in FENO 24 hours after exercise in the groups of asthmatic patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2147005&req=5

Figure 2: Changes in FENO 24 hours after exercise in the groups of asthmatic patients.
Mentions: 24 hours after the exercise test, in the group of asthmatics with EIB, a statistically significant increase in FENO (before exercise: 98.90 ppB ± 55.37; 24 hours after exercise: 119.18 ± 64.39; p = 0.034) and BHR to histamine (log PC20FEV1 before exercise: -0.59 mg/ml ± 1.16; 24 hours after exercise: -0.95 ± 1.03; p = 0.0009) was revealed. Figure 2, Figure 3. Such changes were not observed in the group of asthmatic patients without EIB (FENO before exercise: 66.62 ppB ± 23.05; 24 hours after exercise: 67.87 ± 23.03; p = 0.25; log PC20FEV1 before exercise: -0.053 mg/ml ± 0.55; 24 hours after exercise: -0.0511.62 ± 0.59; p = 0.99). In neither group of asthmatics did we detect significant changes in FEV1 24 hours after exercise.

Bottom Line: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood.No effects of the exercise test on changes in the concentrations of ET-1 in EBC in either asthmatic patients without EIB or healthy volunteers were observed.The release of ET-1 from bronchial epithelium through the influence of many inflammatory cells essential in asthma and interactions with other cytokines, may play an important role in increase of airway inflammation which was observed after postexercise bronchoconstriction in asthmatic patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland. z.zietkowski@wp.pl

ABSTRACT

Background: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood. Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides which play an important role in the development of airway inflammation and remodeling in asthma. The aim of the study was to evaluate the changes in endothelin-1 levels in exhaled breath condensate following intensive exercise in asthmatic patients.

Methods: The study was conducted in a group of 19 asthmatic patients (11 with EIB, 8 without EIB) and 7 healthy volunteers. Changes induced by intensive exercise in the concentrations of endothelin-1 (ET-1) in exhaled breath condensate (EBC) during 24 hours after an exercise challenge test were determined. Moreover, the possible correlations of these measurements with the results of other tests commonly associated with asthma and with the changes of airway inflammation after exercise were observed.

Results: In asthmatic patients with EIB a statistically significant increase in the concentration of ET-1 in EBC collected between 10 minutes and 6 hours after an exercise test was observed. The concentration of ET-1 had returned to its initial level 24 hours after exercise. No effects of the exercise test on changes in the concentrations of ET-1 in EBC in either asthmatic patients without EIB or healthy volunteers were observed. A statistically significant correlation between the maximum increase in ET-1 concentrations in EBC after exercise and either baseline FENO and the increase in FENO or BHR to histamine 24 hours after exercise in the groups of asthmatics with EIB was revealed.

Conclusion: The release of ET-1 from bronchial epithelium through the influence of many inflammatory cells essential in asthma and interactions with other cytokines, may play an important role in increase of airway inflammation which was observed after postexercise bronchoconstriction in asthmatic patients.

Show MeSH
Related in: MedlinePlus