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The oral cavity and age: a site of chronic inflammation?

Bäck M, Hlawaty H, Labat C, Michel JB, Brink C - PLoS ONE (2007)

Bottom Line: Saliva from healthy subjects (< or =40 years) compared with data derived from older volunteers (>40 years) demonstrated a significant increase in the mean values for PGE(2) and MMP-9 activity with age.In addition, significant correlations were observed between LTB(4) and PGE(2) (r = 0.28; P<0.05; n = 56) and between LTB(4) levels and MMP-9 activity in smokers (r = 0.78; P<0.001; n = 15).The presence of significant levels and activity of inflammatory mediators in saliva suggests that the oral cavity of healthy subjects may be in a constant low state of inflammation associated with age.

View Article: PubMed Central - PubMed

Affiliation: INSERM U698, University of Paris 7, Bichat Hospital, Paris, France.

ABSTRACT

Background: Aging may be accompanied by a low grade chronic up-regulation of inflammatory mediators. A variety of endogenous locally released mediators as well as inflammatory cells have been reported in the human oral cavity. The aim of this investigation was to determine the presence of different classes of inflammatory mediators in human saliva and correlate the levels with age.

Methodology and principal findings: Unstimulated whole buccal salivary samples were obtained in the morning from 94 healthy volunteers within 30 minutes after waking. None of the participants had taken aspirin in the week prior to the saliva collection. Lysozyme activity, eicosanoid levels (prostaglandin E(2) and leukotriene B(4)) and MMP-9 activity were measured. The antimicrobial activity (lysozyme activity) was not correlated with age whereas PGE(2) levels were markedly correlated with age (r = 0.29; P<0.05; n = 56). Saliva from healthy subjects (< or =40 years) compared with data derived from older volunteers (>40 years) demonstrated a significant increase in the mean values for PGE(2) and MMP-9 activity with age. In addition, significant correlations were observed between LTB(4) and PGE(2) (r = 0.28; P<0.05; n = 56) and between LTB(4) levels and MMP-9 activity in smokers (r = 0.78; P<0.001; n = 15).

Conclusions/significance: The presence of significant levels and activity of inflammatory mediators in saliva suggests that the oral cavity of healthy subjects may be in a constant low state of inflammation associated with age.

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Related in: MedlinePlus

Relationship between age and mediators of inflammation in saliva from healthy subjects.Panel a: lysozyme activity, b: PGE2, c: LTB4 (with inset showing ≤40 years) and d: MMP-9 activity. Diagonal lines are the regression correlations when shown to be significant.
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pone-0001351-g001: Relationship between age and mediators of inflammation in saliva from healthy subjects.Panel a: lysozyme activity, b: PGE2, c: LTB4 (with inset showing ≤40 years) and d: MMP-9 activity. Diagonal lines are the regression correlations when shown to be significant.

Mentions: The lysozyme activity measured in human saliva was not correlated with age (Fig 1a; n = 94). In contrast, the data presented in Figure 1 indicate a significant correlation with age for PGE2 (Fig 1b; n = 56) with about 2-fold higher salivary levels of PGE2 in the subjects older than 40 years of age compared with those below 40 years (Table 2).


The oral cavity and age: a site of chronic inflammation?

Bäck M, Hlawaty H, Labat C, Michel JB, Brink C - PLoS ONE (2007)

Relationship between age and mediators of inflammation in saliva from healthy subjects.Panel a: lysozyme activity, b: PGE2, c: LTB4 (with inset showing ≤40 years) and d: MMP-9 activity. Diagonal lines are the regression correlations when shown to be significant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2131777&req=5

pone-0001351-g001: Relationship between age and mediators of inflammation in saliva from healthy subjects.Panel a: lysozyme activity, b: PGE2, c: LTB4 (with inset showing ≤40 years) and d: MMP-9 activity. Diagonal lines are the regression correlations when shown to be significant.
Mentions: The lysozyme activity measured in human saliva was not correlated with age (Fig 1a; n = 94). In contrast, the data presented in Figure 1 indicate a significant correlation with age for PGE2 (Fig 1b; n = 56) with about 2-fold higher salivary levels of PGE2 in the subjects older than 40 years of age compared with those below 40 years (Table 2).

Bottom Line: Saliva from healthy subjects (< or =40 years) compared with data derived from older volunteers (>40 years) demonstrated a significant increase in the mean values for PGE(2) and MMP-9 activity with age.In addition, significant correlations were observed between LTB(4) and PGE(2) (r = 0.28; P<0.05; n = 56) and between LTB(4) levels and MMP-9 activity in smokers (r = 0.78; P<0.001; n = 15).The presence of significant levels and activity of inflammatory mediators in saliva suggests that the oral cavity of healthy subjects may be in a constant low state of inflammation associated with age.

View Article: PubMed Central - PubMed

Affiliation: INSERM U698, University of Paris 7, Bichat Hospital, Paris, France.

ABSTRACT

Background: Aging may be accompanied by a low grade chronic up-regulation of inflammatory mediators. A variety of endogenous locally released mediators as well as inflammatory cells have been reported in the human oral cavity. The aim of this investigation was to determine the presence of different classes of inflammatory mediators in human saliva and correlate the levels with age.

Methodology and principal findings: Unstimulated whole buccal salivary samples were obtained in the morning from 94 healthy volunteers within 30 minutes after waking. None of the participants had taken aspirin in the week prior to the saliva collection. Lysozyme activity, eicosanoid levels (prostaglandin E(2) and leukotriene B(4)) and MMP-9 activity were measured. The antimicrobial activity (lysozyme activity) was not correlated with age whereas PGE(2) levels were markedly correlated with age (r = 0.29; P<0.05; n = 56). Saliva from healthy subjects (< or =40 years) compared with data derived from older volunteers (>40 years) demonstrated a significant increase in the mean values for PGE(2) and MMP-9 activity with age. In addition, significant correlations were observed between LTB(4) and PGE(2) (r = 0.28; P<0.05; n = 56) and between LTB(4) levels and MMP-9 activity in smokers (r = 0.78; P<0.001; n = 15).

Conclusions/significance: The presence of significant levels and activity of inflammatory mediators in saliva suggests that the oral cavity of healthy subjects may be in a constant low state of inflammation associated with age.

Show MeSH
Related in: MedlinePlus