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Th1/Th2 cross-regulation and the discovery of IL-10.

Bashyam H - J. Exp. Med. (2007)

Bottom Line: In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory.Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

View Article: PubMed Central - PubMed

Affiliation: hbashyam@rockefeller.edu

ABSTRACT
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

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Tim Mosmann
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fig1: Tim Mosmann


Th1/Th2 cross-regulation and the discovery of IL-10.

Bashyam H - J. Exp. Med. (2007)

Tim Mosmann
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2118739&req=5

fig1: Tim Mosmann
Bottom Line: In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory.Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

View Article: PubMed Central - PubMed

Affiliation: hbashyam@rockefeller.edu

ABSTRACT
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

Show MeSH