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A MyD88 meddles with survival

View Article: PubMed Central

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In the MyD88 family of cytosolic adaptor proteins, the newest member is the group's black sheep, according to Kim et al. (page 2063)... MyD88-1–4 all respond to Toll-like receptor (TLR) activation in leukocytes and stimulate innate immune responses... MyD88-5, however, does not transmit TLR signals or induce innate response genes... Two extra domains in MyD88-5 that may allow it to interact with cytoskeletal proteins hint at an entirely different function... Kim et al. now find that the protein is not even expressed in most leukocytes and instead is found mainly in neurons... But how MyD88-5 levels are controlled within the neuron remains to be determined... MyD88-5 also recruited JNK3, a kinase whose association with mitochondria activates apoptosis in stressed cells... The stress of UV light increased the association of JNK3 with MyD88-5, and neurons from mice lacking MyD88-5 were less vulnerable to stress-induced apoptosis... The authors are now using mouse models of brain injury to investigate whether the absence of MyD88-5 saves damaged neurons during, for example, a stroke... T cells also expressed some MyD88-5... Because these cells lack JNK3, the adaptor probably has additional binding partners.

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Proapoptotic JNK3 (yellow) clusters near mitochondria (red) only when MyD88-5 (green) is present.
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fig1: Proapoptotic JNK3 (yellow) clusters near mitochondria (red) only when MyD88-5 (green) is present.


A MyD88 meddles with survival
Proapoptotic JNK3 (yellow) clusters near mitochondria (red) only when MyD88-5 (green) is present.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2118709&req=5

fig1: Proapoptotic JNK3 (yellow) clusters near mitochondria (red) only when MyD88-5 (green) is present.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In the MyD88 family of cytosolic adaptor proteins, the newest member is the group's black sheep, according to Kim et al. (page 2063)... MyD88-1–4 all respond to Toll-like receptor (TLR) activation in leukocytes and stimulate innate immune responses... MyD88-5, however, does not transmit TLR signals or induce innate response genes... Two extra domains in MyD88-5 that may allow it to interact with cytoskeletal proteins hint at an entirely different function... Kim et al. now find that the protein is not even expressed in most leukocytes and instead is found mainly in neurons... But how MyD88-5 levels are controlled within the neuron remains to be determined... MyD88-5 also recruited JNK3, a kinase whose association with mitochondria activates apoptosis in stressed cells... The stress of UV light increased the association of JNK3 with MyD88-5, and neurons from mice lacking MyD88-5 were less vulnerable to stress-induced apoptosis... The authors are now using mouse models of brain injury to investigate whether the absence of MyD88-5 saves damaged neurons during, for example, a stroke... T cells also expressed some MyD88-5... Because these cells lack JNK3, the adaptor probably has additional binding partners.

No MeSH data available.