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Geometric triangular chiral hexagon crystal-like complexes organization in pathological tissues biological collision order.

Díaz JA, Jaramillo NA, Murillo MF - PLoS ONE (2007)

Bottom Line: In their experimental model, the authors were able to reproduce and to predict polarity, chirality, helicoid geometry, triangular and hexagonal clusters through electromagnetic sequential collisions.They determined that similar events among constituents of extracelular matrix which drive and produce piezoelectric activity are responsible for the genesis of GTCHC complexes in pathological tissues.This research suggests that molecular crystals represented by triangular chiral hexagons derived from a collision-attraction event against collagen type I fibrils emerge at microscopic and macroscopic scales presenting a lateral assembly of each side of hypertrophy helicoid fibers, that represent energy flow in cooperative hierarchically chiral electromagnetic interaction in pathological tissues and arises as a geometry of the equilibrium in perturbed biological systems.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pathology, Department of Pathology, Clinic Health Social Entity Policarpa Salavarrieta, University Cooperativa of Colombia, Medicine School, Villavicencio, Meta, Colombia. jaditod@hotmail.com

ABSTRACT
The present study describes and documents self-assembly of geometric triangular chiral hexagon crystal like complex organizations (GTCHC) in human pathological tissues. The authors have found this architectural geometric expression at macroscopic and microscopic levels mainly in cancer processes. This study is based essentially on macroscopic and histopathologic analyses of 3000 surgical specimens: 2600 inflammatory lesions and 400 malignant tumours. Geometric complexes identified photographically at macroscopic level were located in the gross surgical specimen, and these areas were carefully dissected. Samples were taken to carry out histologic analysis. Based on the hypothesis of a collision genesis mechanism and because it is difficult to carry out an appropriate methodological observation in biological systems, the authors designed a model base on other dynamic systems to obtain indirect information in which a strong white flash wave light discharge, generated by an electronic device, hits over the lines of electrical conductance structured in helicoidal pattern. In their experimental model, the authors were able to reproduce and to predict polarity, chirality, helicoid geometry, triangular and hexagonal clusters through electromagnetic sequential collisions. They determined that similar events among constituents of extracelular matrix which drive and produce piezoelectric activity are responsible for the genesis of GTCHC complexes in pathological tissues. This research suggests that molecular crystals represented by triangular chiral hexagons derived from a collision-attraction event against collagen type I fibrils emerge at microscopic and macroscopic scales presenting a lateral assembly of each side of hypertrophy helicoid fibers, that represent energy flow in cooperative hierarchically chiral electromagnetic interaction in pathological tissues and arises as a geometry of the equilibrium in perturbed biological systems. Further interdisciplinary studies must be carried out to reproduce, manipulate and amplify their activity and probably use them as a base to develop new therapeutic strategies in cancer.

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Geometric Triangular chiral hexagon cristal like complexes assembled from helicoid pattern.Panel A. Microscopic GTCHC complex in prostate adenocarcinoma. Panel B. Macroscopic GTCHC complex in liposarcoma. Panel C. Microscopic GTCHC complex in lipoma .Helicoid border. Panel D. Macroscopic GTCHC complex in breast cancer. Observe how the straight lines are assembled from helicoid border pattern. Panel E. Full view of GTCHC complex, this is the same as panel D after demarcating and cleaning the area. It is possible equally to identify “hole” microcavities in their surface. Panel F. Macroscopic GTCHC complex in filloid breast tumor with helicoid border pattern. We appreciate the initial formation of hole microcavities concluding in changes of cystic degeneration at the interior of the geometric complex.
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pone-0001282-g002: Geometric Triangular chiral hexagon cristal like complexes assembled from helicoid pattern.Panel A. Microscopic GTCHC complex in prostate adenocarcinoma. Panel B. Macroscopic GTCHC complex in liposarcoma. Panel C. Microscopic GTCHC complex in lipoma .Helicoid border. Panel D. Macroscopic GTCHC complex in breast cancer. Observe how the straight lines are assembled from helicoid border pattern. Panel E. Full view of GTCHC complex, this is the same as panel D after demarcating and cleaning the area. It is possible equally to identify “hole” microcavities in their surface. Panel F. Macroscopic GTCHC complex in filloid breast tumor with helicoid border pattern. We appreciate the initial formation of hole microcavities concluding in changes of cystic degeneration at the interior of the geometric complex.

Mentions: From 2600 random inflammatory–immunologic processes analyzed, the authors identified images of triangular chiral counterpart tissue configuration in 312 cases (12%). From 400 cancer processes analyzed, geometric complexes were identified in 216 cases (54%). These percentages show identification of highly ordered structures in more than 50% of the analyzed malignant tumor tissues statistically significant (P = 0.00001) (Table 1). The organizations were observed with more frequency under tumor conditions (Figures 1–8) however also under benign condition (Figures 7D,7E ,7F, ). Sarcoma lesions of greater size were those that evidence more clear complex GTCHC (Figures 1D, 2B, 2F, 3A, 3B, 4D).


Geometric triangular chiral hexagon crystal-like complexes organization in pathological tissues biological collision order.

Díaz JA, Jaramillo NA, Murillo MF - PLoS ONE (2007)

Geometric Triangular chiral hexagon cristal like complexes assembled from helicoid pattern.Panel A. Microscopic GTCHC complex in prostate adenocarcinoma. Panel B. Macroscopic GTCHC complex in liposarcoma. Panel C. Microscopic GTCHC complex in lipoma .Helicoid border. Panel D. Macroscopic GTCHC complex in breast cancer. Observe how the straight lines are assembled from helicoid border pattern. Panel E. Full view of GTCHC complex, this is the same as panel D after demarcating and cleaning the area. It is possible equally to identify “hole” microcavities in their surface. Panel F. Macroscopic GTCHC complex in filloid breast tumor with helicoid border pattern. We appreciate the initial formation of hole microcavities concluding in changes of cystic degeneration at the interior of the geometric complex.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2100170&req=5

pone-0001282-g002: Geometric Triangular chiral hexagon cristal like complexes assembled from helicoid pattern.Panel A. Microscopic GTCHC complex in prostate adenocarcinoma. Panel B. Macroscopic GTCHC complex in liposarcoma. Panel C. Microscopic GTCHC complex in lipoma .Helicoid border. Panel D. Macroscopic GTCHC complex in breast cancer. Observe how the straight lines are assembled from helicoid border pattern. Panel E. Full view of GTCHC complex, this is the same as panel D after demarcating and cleaning the area. It is possible equally to identify “hole” microcavities in their surface. Panel F. Macroscopic GTCHC complex in filloid breast tumor with helicoid border pattern. We appreciate the initial formation of hole microcavities concluding in changes of cystic degeneration at the interior of the geometric complex.
Mentions: From 2600 random inflammatory–immunologic processes analyzed, the authors identified images of triangular chiral counterpart tissue configuration in 312 cases (12%). From 400 cancer processes analyzed, geometric complexes were identified in 216 cases (54%). These percentages show identification of highly ordered structures in more than 50% of the analyzed malignant tumor tissues statistically significant (P = 0.00001) (Table 1). The organizations were observed with more frequency under tumor conditions (Figures 1–8) however also under benign condition (Figures 7D,7E ,7F, ). Sarcoma lesions of greater size were those that evidence more clear complex GTCHC (Figures 1D, 2B, 2F, 3A, 3B, 4D).

Bottom Line: In their experimental model, the authors were able to reproduce and to predict polarity, chirality, helicoid geometry, triangular and hexagonal clusters through electromagnetic sequential collisions.They determined that similar events among constituents of extracelular matrix which drive and produce piezoelectric activity are responsible for the genesis of GTCHC complexes in pathological tissues.This research suggests that molecular crystals represented by triangular chiral hexagons derived from a collision-attraction event against collagen type I fibrils emerge at microscopic and macroscopic scales presenting a lateral assembly of each side of hypertrophy helicoid fibers, that represent energy flow in cooperative hierarchically chiral electromagnetic interaction in pathological tissues and arises as a geometry of the equilibrium in perturbed biological systems.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pathology, Department of Pathology, Clinic Health Social Entity Policarpa Salavarrieta, University Cooperativa of Colombia, Medicine School, Villavicencio, Meta, Colombia. jaditod@hotmail.com

ABSTRACT
The present study describes and documents self-assembly of geometric triangular chiral hexagon crystal like complex organizations (GTCHC) in human pathological tissues. The authors have found this architectural geometric expression at macroscopic and microscopic levels mainly in cancer processes. This study is based essentially on macroscopic and histopathologic analyses of 3000 surgical specimens: 2600 inflammatory lesions and 400 malignant tumours. Geometric complexes identified photographically at macroscopic level were located in the gross surgical specimen, and these areas were carefully dissected. Samples were taken to carry out histologic analysis. Based on the hypothesis of a collision genesis mechanism and because it is difficult to carry out an appropriate methodological observation in biological systems, the authors designed a model base on other dynamic systems to obtain indirect information in which a strong white flash wave light discharge, generated by an electronic device, hits over the lines of electrical conductance structured in helicoidal pattern. In their experimental model, the authors were able to reproduce and to predict polarity, chirality, helicoid geometry, triangular and hexagonal clusters through electromagnetic sequential collisions. They determined that similar events among constituents of extracelular matrix which drive and produce piezoelectric activity are responsible for the genesis of GTCHC complexes in pathological tissues. This research suggests that molecular crystals represented by triangular chiral hexagons derived from a collision-attraction event against collagen type I fibrils emerge at microscopic and macroscopic scales presenting a lateral assembly of each side of hypertrophy helicoid fibers, that represent energy flow in cooperative hierarchically chiral electromagnetic interaction in pathological tissues and arises as a geometry of the equilibrium in perturbed biological systems. Further interdisciplinary studies must be carried out to reproduce, manipulate and amplify their activity and probably use them as a base to develop new therapeutic strategies in cancer.

Show MeSH
Related in: MedlinePlus