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A human testicular teratoma serially transplanted in immune-deprived mice.

Selby PJ, Heyderman E, Gibbs J, Peckham MJ - Br. J. Cancer (1979)

Bottom Line: Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described.The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate.It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.

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ABSTRACT
Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.

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A human testicular teratoma serially transplanted in immune-deprived mice.

Selby PJ, Heyderman E, Gibbs J, Peckham MJ - Br. J. Cancer (1979)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009907&req=5

Bottom Line: Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described.The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate.It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.

View Article: PubMed Central - PubMed

ABSTRACT
Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.

Show MeSH
Related in: MedlinePlus