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Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.

Rostom AY, Kauffman SL, Steel GG - Br. J. Cancer (1978)

Bottom Line: There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine.When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant.However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum.

View Article: PubMed Central - PubMed

ABSTRACT
C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum.

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Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.

Rostom AY, Kauffman SL, Steel GG - Br. J. Cancer (1978)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009771&req=5

Bottom Line: There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine.When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant.However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum.

View Article: PubMed Central - PubMed

ABSTRACT
C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum.

Show MeSH
Related in: MedlinePlus