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Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.

Jun MH, Johnson RH, Maguire DJ, Hopkins PS - Br. J. Cancer (1978)

Bottom Line: At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined.Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development.The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

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ABSTRACT
Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

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Related in: MedlinePlus

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Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.

Jun MH, Johnson RH, Maguire DJ, Hopkins PS - Br. J. Cancer (1978)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009732&req=5

Bottom Line: At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined.Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development.The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

View Article: PubMed Central - PubMed

ABSTRACT
Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

Show MeSH
Related in: MedlinePlus