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Malignant neoplasms in rats fed lasiocarpine.

Rao MS, Reddy JK - Br. J. Cancer (1978)

Bottom Line: Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas.Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma.From one animal, angiosarcoma was successfully transplanted through 4 generations.

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ABSTRACT
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

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Related in: MedlinePlus

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Malignant neoplasms in rats fed lasiocarpine.

Rao MS, Reddy JK - Br. J. Cancer (1978)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009590&req=5

Bottom Line: Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas.Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma.From one animal, angiosarcoma was successfully transplanted through 4 generations.

View Article: PubMed Central - PubMed

ABSTRACT
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

Show MeSH
Related in: MedlinePlus