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Serial cytogenetic studies of human colonic tumour xenografts.
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Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice.In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines.In the other tumour there was selection for a sideline containing a particular deleted marker chromosome.
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ABSTRACT
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Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed. Related in: MedlinePlus |
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View Article: PubMed Central - PubMed
