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Serial cytogenetic studies of human colonic tumour xenografts.

Reeves BR, Houghton JA - Br. J. Cancer (1978)

Bottom Line: Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice.In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines.In the other tumour there was selection for a sideline containing a particular deleted marker chromosome.

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ABSTRACT
Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed.

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Related in: MedlinePlus

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Serial cytogenetic studies of human colonic tumour xenografts.

Reeves BR, Houghton JA - Br. J. Cancer (1978)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009546&req=5

Bottom Line: Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice.In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines.In the other tumour there was selection for a sideline containing a particular deleted marker chromosome.

View Article: PubMed Central - PubMed

ABSTRACT
Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed.

Show MeSH
Related in: MedlinePlus