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Glial fibrillary acidic protein in tumours of the nervous system.

Delpech B, Delpech A, Vidard MN, Girard N, Tayot J, Clement JC, Creissard P - Br. J. Cancer (1978)

Bottom Line: We conclude that GFA is a specific marker of both malignant and normal astrocytes.Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA.Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

View Article: PubMed Central - PubMed

ABSTRACT
Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

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Related in: MedlinePlus

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Glial fibrillary acidic protein in tumours of the nervous system.

Delpech B, Delpech A, Vidard MN, Girard N, Tayot J, Clement JC, Creissard P - Br. J. Cancer (1978)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009497&req=5

Bottom Line: We conclude that GFA is a specific marker of both malignant and normal astrocytes.Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA.Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

View Article: PubMed Central - PubMed

ABSTRACT
Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

Show MeSH
Related in: MedlinePlus