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Photodynamic destruction of human bladder carcinoma.

Kelly JF, Snell ME, Berenbaum MC - Br. J. Cancer (1975)

Bottom Line: The administration of a haematoporphyrin derivative (HpD), followed 24 h later by exposure to white light, caused marked destruction of tumours but little or none of normal bladder tissues.HpD or light alone caused no damage to tumours or normal tissues.It is suggested that photodynamic therapy may be applicable in the treatment of superficial transitional cell carcinoma of the bladder.

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ABSTRACT
Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. The administration of a haematoporphyrin derivative (HpD), followed 24 h later by exposure to white light, caused marked destruction of tumours but little or none of normal bladder tissues. HpD or light alone caused no damage to tumours or normal tissues. It is suggested that photodynamic therapy may be applicable in the treatment of superficial transitional cell carcinoma of the bladder.

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Photodynamic destruction of human bladder carcinoma.

Kelly JF, Snell ME, Berenbaum MC - Br. J. Cancer (1975)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009375&req=5

Bottom Line: The administration of a haematoporphyrin derivative (HpD), followed 24 h later by exposure to white light, caused marked destruction of tumours but little or none of normal bladder tissues.HpD or light alone caused no damage to tumours or normal tissues.It is suggested that photodynamic therapy may be applicable in the treatment of superficial transitional cell carcinoma of the bladder.

View Article: PubMed Central - PubMed

ABSTRACT
Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. The administration of a haematoporphyrin derivative (HpD), followed 24 h later by exposure to white light, caused marked destruction of tumours but little or none of normal bladder tissues. HpD or light alone caused no damage to tumours or normal tissues. It is suggested that photodynamic therapy may be applicable in the treatment of superficial transitional cell carcinoma of the bladder.

Show MeSH
Related in: MedlinePlus