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On the theory of clonal selection in carcinogenic transformation.

Naha PM, Ashworth M - Br. J. Cancer (1974)

Bottom Line: A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C.Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.

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ABSTRACT
A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.

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On the theory of clonal selection in carcinogenic transformation.

Naha PM, Ashworth M - Br. J. Cancer (1974)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2009312&req=5

Bottom Line: A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C.Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.

View Article: PubMed Central - PubMed

ABSTRACT
A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.

Show MeSH
Related in: MedlinePlus