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Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults.

Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T - PLoS ONE (2007)

Bottom Line: Aging is associated with lower muscle mass and an increase in body fat.Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides).Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada. tarnopol@mcmaster.ca

ABSTRACT
Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides). Exercise training improved all measurements of functional capacity (P<0.05) and strength (P<0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P<0.05). Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests. Together, this data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period. Trial Registration. ClinicalTrials.gov NCT00473902.

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Summary of the recruitment strategy and allocation.
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pone-0000991-g001: Summary of the recruitment strategy and allocation.

Mentions: After the initial screening, the subjects were required to perform a cycle ergometry test to 5 METS (metabolic equivalents) on a mechanically braked cycle ergometer (Monarch, Varberg, Sweden). A 12-lead electrocardiogram (ECG, Burdick, Kone Instruments Corp., Espoo, Finland) was taken prior to and upon completion of the ergometry test, as part of exclusion criteria to participate in the resistance exercise training program. Any participants with abnormal resting ECG's or a blood pressure of >160 mmHg systolic and/or 95 mmHg diastolic were not allowed to complete the screening tests. One subject with questionable post-exercise exercise ECG changes was referred to a cardiologist for assessment and was cleared to participate in the study. A summary of the recruitment strategy and allocation is presented in Figure 1.


Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults.

Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T - PLoS ONE (2007)

Summary of the recruitment strategy and allocation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1994592&req=5

pone-0000991-g001: Summary of the recruitment strategy and allocation.
Mentions: After the initial screening, the subjects were required to perform a cycle ergometry test to 5 METS (metabolic equivalents) on a mechanically braked cycle ergometer (Monarch, Varberg, Sweden). A 12-lead electrocardiogram (ECG, Burdick, Kone Instruments Corp., Espoo, Finland) was taken prior to and upon completion of the ergometry test, as part of exclusion criteria to participate in the resistance exercise training program. Any participants with abnormal resting ECG's or a blood pressure of >160 mmHg systolic and/or 95 mmHg diastolic were not allowed to complete the screening tests. One subject with questionable post-exercise exercise ECG changes was referred to a cardiologist for assessment and was cleared to participate in the study. A summary of the recruitment strategy and allocation is presented in Figure 1.

Bottom Line: Aging is associated with lower muscle mass and an increase in body fat.Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides).Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada. tarnopol@mcmaster.ca

ABSTRACT
Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides). Exercise training improved all measurements of functional capacity (P<0.05) and strength (P<0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P<0.05). Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests. Together, this data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period. Trial Registration. ClinicalTrials.gov NCT00473902.

Show MeSH