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Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).

Livingston DM, Kaelin W, Chittenden T, Qin X - Br. J. Cancer (1993)

Bottom Line: After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S.Here, we review a series of results which speak to the elements of RB structure which contribute to this activity.Included is its internal colinear protein receptor domain (i.e. the 'pocket').

View Article: PubMed Central - PubMed

Affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.

ABSTRACT
The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket').

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Related in: MedlinePlus

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Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).

Livingston DM, Kaelin W, Chittenden T, Qin X - Br. J. Cancer (1993)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1968582&req=5

Bottom Line: After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S.Here, we review a series of results which speak to the elements of RB structure which contribute to this activity.Included is its internal colinear protein receptor domain (i.e. the 'pocket').

View Article: PubMed Central - PubMed

Affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.

ABSTRACT
The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket').

Show MeSH
Related in: MedlinePlus